Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0038 | 0.1153 | 0.1153 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0161 | 0.0161 |
Brugia malayi | Carboxylesterase family protein | 0.0038 | 0.1153 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3075 | 0.3075 |
Brugia malayi | Carboxylesterase family protein | 0.0038 | 0.1153 | 0.1535 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0154 | 0.6278 | 0.6278 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.7516 | 0.7516 |
Schistosoma mansoni | hypothetical protein | 0.0239 | 1 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0239 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0038 | 0.1153 | 0.1153 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0126 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0287 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1153 | 0.1153 |
Echinococcus granulosus | acetylcholinesterase | 0.0038 | 0.1153 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0161 | 0.0161 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2709 | 0.2709 |
Echinococcus granulosus | acetylcholinesterase | 0.0038 | 0.1153 | 0.1153 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0038 | 0.1153 | 0.1153 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.7516 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0038 | 0.1153 | 0.1153 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0287 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2882 | 0.2882 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | carboxylesterase | 0.0038 | 0.1153 | 0.1153 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0126 | 0.0126 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0126 | 0.0126 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0038 | 0.1153 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1153 | 0.1153 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0287 | 0.0287 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0038 | 0.1153 | 0.1153 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0126 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0287 | 0.0287 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.6989 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 190 nM | Inhibitory concentration against Vascular endothelial growth factor receptor 2 | ChEMBL. | 15713401 |
IC50 (binding) | = 190 nM | Inhibitory concentration against Vascular endothelial growth factor receptor 2 | ChEMBL. | 15713401 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.