Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0163 | 1 | 1 | |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0138 | 0.7701 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0055 | 0 | 0.5 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0163 | 1 | 1 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0163 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0123 | 0.636 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0138 | 0.7701 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0138 | 0.7701 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0138 | 0.7701 | 0.7701 |
Trypanosoma brucei | Prostaglandin E synthase | 0.0163 | 1 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0138 | 0.7701 | 0.7701 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0138 | 0.7701 | 0.7701 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0163 | 1 | 1 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0138 | 0.7701 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.