Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.05 | 0.7082 | 0.5 |
Brugia malayi | thymidylate synthase | 0.05 | 0.7082 | 0.7082 |
Echinococcus granulosus | thymidylate synthase | 0.05 | 0.7082 | 0.7082 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.05 | 0.7082 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.05 | 0.7082 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.05 | 0.7082 | 1 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0693 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0238 | 0.3134 | 0.3134 |
Loa Loa (eye worm) | thymidylate synthase | 0.05 | 0.7082 | 0.7082 |
Mycobacterium ulcerans | thymidylate synthase | 0.05 | 0.7082 | 0.5 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0693 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.2566 | 0.1265 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.0693 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0238 | 0.3134 | 0.2941 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0238 | 0.3134 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.05 | 0.7082 | 0.5 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.0693 | 1 | 1 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0129 | 0.1489 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.05 | 0.7082 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0238 | 0.3134 | 0.2941 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.05 | 0.7082 | 0.6571 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.05 | 0.7082 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.05 | 0.7082 | 0.7082 |
Onchocerca volvulus | 0.05 | 0.7082 | 0.5 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.05 | 0.7082 | 1 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0129 | 0.1489 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.8 uM | Inhibitory concentration against human calcium receptor expressed in HEK 293 cells | ChEMBL. | 15745796 |
IC50 (binding) | = 0.8 uM | Inhibitory concentration against human calcium receptor expressed in HEK 293 cells | ChEMBL. | 15745796 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.