Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0403 | 0.5 |
Onchocerca volvulus | 0.0383 | 1 | 1 | |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0403 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0717 | 0.0328 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0717 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0403 | 0.5614 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0403 | 0.5614 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0403 | 0.5 |
Onchocerca volvulus | 0.0383 | 1 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0403 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0264 | 0.6671 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0403 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0383 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0717 | 0.0328 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0717 | 0.0328 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0383 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0383 | 1 | 1 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0383 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0383 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0383 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0403 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0403 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.0383 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0383 | 1 | 1 |
Onchocerca volvulus | 0.0383 | 1 | 1 | |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0403 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0383 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0403 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0717 | 0.0328 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0403 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0403 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0403 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0403 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0403 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0717 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0717 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0403 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0403 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0383 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0403 | 1 |
Onchocerca volvulus | 0.0383 | 1 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0717 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0403 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0717 | 0.0328 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0403 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 16 ug ml-1 | Minimum inhibitory concentration of the compound against Mycobacterium tuberculosis H37Rv ATCC 27294 | ChEMBL. | 15745799 |
MIC (functional) | > 16 ug ml-1 | Minimum inhibitory concentration of the compound against sensitive Mycobacterium tuberculosis clinical isolates; N=9 | ChEMBL. | 15745799 |
MIC (functional) | > 16 ug ml-1 | Minimum inhibitory concentration of the compound against resistant Mycobacterium tuberculosis clinical isolates; N=9 | ChEMBL. | 15745799 |
MIC (functional) | > 16 ug ml-1 | Minimum inhibitory concentration of the compound against Mycobacterium tuberculosis H37Rv ATCC 27294 | ChEMBL. | 15745799 |
MIC (functional) | > 16 ug ml-1 | Minimum inhibitory concentration of the compound against sensitive Mycobacterium tuberculosis clinical isolates; N=9 | ChEMBL. | 15745799 |
MIC (functional) | > 16 ug ml-1 | Minimum inhibitory concentration of the compound against resistant Mycobacterium tuberculosis clinical isolates; N=9 | ChEMBL. | 15745799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.