Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | phosphoenolpyruvate carboxykinase | 0.0698 | 1 | 1 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0698 | 1 | 1 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0698 | 1 | 1 |
Treponema pallidum | phosphoenolpyruvate carboxykinase | 0.0698 | 1 | 1 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0698 | 1 | 1 |
Loa Loa (eye worm) | phosphoenolpyruvate carboxykinase cytosolic family member | 0.0698 | 1 | 1 |
Mycobacterium ulcerans | phosphoenolpyruvate carboxykinase | 0.0698 | 1 | 1 |
Brugia malayi | phosphoenolpyruvate carboxykinase [GTP] | 0.0698 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0262 | 0.2408 | 0.1715 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0214 | 0.1571 | 0.0802 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0698 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0223 | 0.1732 | 0.0977 |
Loa Loa (eye worm) | phosphoenolpyruvate carboxykinase | 0.0698 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0391 | 0.4648 | 0.4159 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0223 | 0.1732 | 0.0977 |
Onchocerca volvulus | 0.0582 | 0.7974 | 0.5 | |
Echinococcus multilocularis | glutamate receptor 2 | 0.0216 | 0.1603 | 0.0836 |
Mycobacterium tuberculosis | Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase | 0.0698 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0262 | 0.2408 | 0.1715 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0391 | 0.4648 | 0.4159 |
Brugia malayi | hypothetical protein | 0.0255 | 0.2292 | 0.0821 |
Chlamydia trachomatis | phosphoenolpyruvate carboxykinase | 0.0698 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0216 | 0.1603 | 0.0836 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0177 | 0.0926 | 0.0098 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0582 | 0.7974 | 0.6434 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0262 | 0.2408 | 0.1715 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0439 | 0.5485 | 0.4623 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0582 | 0.7974 | 0.6434 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0216 | 0.1603 | 0.0836 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0262 | 0.2408 | 0.1715 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0177 | 0.0926 | 0.0098 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0698 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0262 | 0.2408 | 0.1715 |
Mycobacterium leprae | PROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) (PEPCK)(PEP CARBOXYKINASE | 0.0698 | 1 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0262 | 0.2408 | 0.1715 |
Schistosoma mansoni | phosphoenolpyruvate carboxykinase | 0.0698 | 1 | 1 |
Giardia lamblia | Phosphoenolpyruvate carboxykinase | 0.0698 | 1 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0262 | 0.2408 | 0.1715 |
Echinococcus granulosus | glutamate receptor 2 | 0.0262 | 0.2408 | 0.1715 |
Echinococcus multilocularis | phosphoenolpyruvate carboxykinase | 0.0698 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0262 | 0.2408 | 0.1715 |
Loa Loa (eye worm) | hypothetical protein | 0.0698 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0262 | 0.2408 | 0.1715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.9 uM | Inhibitory activity against Neuronal nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | = 9.9 uM | Inhibitory activity against Neuronal nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | > 50 uM | Inhibitory activity against Inducible nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | > 50 uM | Inhibitory activity against Endothelial nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | > 50 uM | Inhibitory activity against Inducible nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | > 50 uM | Inhibitory activity against Endothelial nitric oxide synthase | ChEMBL. | 15357988 |
Ratio (binding) | 0 uM | Ratio between Endothelial nitric oxide synthase and Inducible nitric oxide synthase; Not determined | ChEMBL. | 15357988 |
Ratio (binding) | 0 uM | Ratio between Neuronal nitric oxide synthase and Inducible nitric oxide synthase; Not determined | ChEMBL. | 15357988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.