pI: 5.5895 |
Length (AA): 599 |
MW (Da): 66245 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 598 | 4wpt (A) | 8 | 605 | 53.00 | 0 | 1 | 1.70809 | -1.13 |
12 | 599 | 2faf (A) | 43 | 639 | 50.00 | 0 | 1 | 1.61184 | -1.14 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129007)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_17155 | phosphoenolpyruvate carboxykinase [GTP] |
Brugia malayi | Bm1_25195 | phosphoenolpyruvate carboxykinase [GTP] |
Caenorhabditis elegans | CELE_R11A5.4 | Protein PCK-2, isoform C |
Caenorhabditis elegans | CELE_W05G11.6 | Protein PCK-1, isoform C |
Chlamydia trachomatis | CT_710 | phosphoenolpyruvate carboxykinase |
Dictyostelium discoideum | DDB_G0271904 | phosphoenolpyruvate carboxykinase |
Drosophila melanogaster | Dmel_CG10924 | CG10924 gene product from transcript CG10924-RA |
Drosophila melanogaster | Dmel_CG17725 | Phosphoenolpyruvate carboxykinase |
Echinococcus granulosus | EgrG_000292700 | phosphoenolpyruvate carboxykinase |
Echinococcus multilocularis | EmuJ_000292700 | phosphoenolpyruvate carboxykinase |
Giardia lamblia | GL50803_10623 | Phosphoenolpyruvate carboxykinase |
Homo sapiens | 5105 | phosphoenolpyruvate carboxykinase 1 (soluble) |
Homo sapiens | ENSG00000100889 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
Loa Loa (eye worm) | LOAG_01890 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07217 | phosphoenolpyruvate carboxykinase |
Loa Loa (eye worm) | LOAG_10229 | phosphoenolpyruvate carboxykinase cytosolic family member |
Mycobacterium leprae | ML2624 | PROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) (PEPCK)(PEP CARBOXYKINASE |
Mus musculus | ENSMUSG00000027513 | phosphoenolpyruvate carboxykinase 1, cytosolic |
Mus musculus | ENSMUSG00000040618 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
Mycobacterium tuberculosis | Rv0211 | Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase |
Mycobacterium ulcerans | MUL_1101 | phosphoenolpyruvate carboxykinase |
Onchocerca volvulus | OVOC1459 |
|
Schistosoma japonicum | Sjp_0202690 | ko:K01596 phosphoenolpyruvate carboxykinase (GTP) [EC4.1.1.32], putative |
Schistosoma mansoni | Smp_005880 | phosphoenolpyruvate carboxykinase |
Schmidtea mediterranea | mk4.001640.00 | |
Schmidtea mediterranea | mk4.018802.00 | |
Schmidtea mediterranea | mk4.000488.07 | |
Schmidtea mediterranea | mk4.003158.00 | Putative phosphoenolpyruvate carboxykinase |
Schmidtea mediterranea | mk4.000512.06 | |
Schmidtea mediterranea | mk4.015910.00 | |
Schmidtea mediterranea | mk4.000556.00 | |
Schmidtea mediterranea | mk4.004453.00 | |
Schmidtea mediterranea | mk4.000512.04 | |
Treponema pallidum | TP0122 | phosphoenolpyruvate carboxykinase |
Trichomonas vaginalis | TVAG_213710 | phosphoenolpyruvate carboxykinase, putative |
Trichomonas vaginalis | TVAG_420390 | phosphoenolpyruvate carboxykinase, putative |
Trichomonas vaginalis | TVAG_314840 | phosphoenolpyruvate carboxykinase, putative |
Trichomonas vaginalis | TVAG_310250 | phosphoenolpyruvate carboxykinase, putative |
Trichomonas vaginalis | TVAG_434120 | phosphoenolpyruvate carboxykinase, putative |
Trichomonas vaginalis | TVAG_139300 | phosphoenolpyruvate carboxykinase, putative |
Trichomonas vaginalis | TVAG_479540 | phosphoenolpyruvate carboxykinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_W05G11.6 | Caenorhabditis elegans | larval lethal | wormbase |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | Compounds | References |
Homo sapiens | phosphoenolpyruvate carboxykinase 1 (soluble) | Compounds | References |