Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | patched 1 | 0.0477 | 0.3251 | 0.3251 |
Echinococcus multilocularis | protein patched | 0.0477 | 0.3251 | 0.3251 |
Loa Loa (eye worm) | hypothetical protein | 0.116 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0544 | 0.391 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.116 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0477 | 0.3251 | 0.3251 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0544 | 0.391 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0477 | 0.3251 | 0.3251 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.116 | 1 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.116 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0477 | 0.3251 | 0.3251 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0477 | 0.3251 | 0.3251 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0477 | 0.3251 | 0.3251 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.116 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0477 | 0.3251 | 0.3251 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0544 | 0.391 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0544 | 0.391 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.116 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.116 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0477 | 0.3251 | 0.3251 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.116 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.116 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 uM | Inhibitory concentration of the compound that gave 50 percent displacement of specific binding of [3H]-AII (2 nM) to Angiotensin II receptor | ChEMBL. | 2329553 |
IC50 (binding) | = 100 uM | Inhibitory concentration of the compound that gave 50 percent displacement of specific binding of [3H]-AII (2 nM) to Angiotensin II receptor | ChEMBL. | 2329553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.