Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0931 | 0.2699 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0889 | 0.2481 | 0.8891 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.2339 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0931 | 0.2699 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0889 | 0.2481 | 0.1883 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0931 | 0.2699 | 0.2118 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0889 | 0.2481 | 0.8891 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0889 | 0.2481 | 0.8891 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0931 | 0.2699 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0931 | 0.2699 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.2339 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.2339 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0889 | 0.2481 | 0.1883 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.2339 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0889 | 0.2481 | 0.1883 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0962 | 0.2863 | 0.2296 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0962 | 0.2863 | 0.2296 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0931 | 0.2699 | 0.2118 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0889 | 0.2481 | 0.1883 |
Schistosoma mansoni | histone deacetylase | 0.0931 | 0.2699 | 0.2118 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0931 | 0.2699 | 0.2118 |
Echinococcus granulosus | histone deacetylase 6 | 0.0962 | 0.2863 | 0.2296 |
Loa Loa (eye worm) | hypothetical protein | 0.0931 | 0.2699 | 0.2699 |
Schistosoma mansoni | histone deacetylase | 0.0931 | 0.2699 | 0.2118 |
Trypanosoma brucei | histone deacetylase, putative | 0.0889 | 0.2481 | 0.8891 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0889 | 0.2481 | 0.1883 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0931 | 0.2699 | 0.2118 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0889 | 0.2481 | 0.2481 |
Echinococcus granulosus | histone deacetylase | 0.0889 | 0.2481 | 0.1883 |
Leishmania major | histone deacetylase, putative | 0.0931 | 0.2699 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0931 | 0.2699 | 0.5 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0889 | 0.2481 | 0.1883 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0931 | 0.2699 | 0.2699 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0931 | 0.2699 | 0.5 |
Entamoeba histolytica | histone deacetylase, putative | 0.0931 | 0.2699 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.0737 | 0.0737 |
Giardia lamblia | Histone deacetylase | 0.0931 | 0.2699 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0889 | 0.2481 | 0.2481 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0931 | 0.2699 | 0.2699 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0931 | 0.2699 | 0.5 |
Echinococcus multilocularis | histone deacetylase | 0.0889 | 0.2481 | 0.1883 |
Mycobacterium leprae | probable uridine phosphorylase | 0.2339 | 1 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0931 | 0.2699 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0889 | 0.2481 | 0.1883 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0931 | 0.2699 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0931 | 0.2699 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0889 | 0.2481 | 0.1883 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0931 | 0.2699 | 0.5 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0552 | 0.0737 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0889 | 0.2481 | 0.1883 |
Leishmania major | histone deacetylase, putative | 0.0931 | 0.2699 | 1 |
Loa Loa (eye worm) | uridine phosphorylase | 0.2339 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0931 | 0.2699 | 0.2118 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0552 | 0.0737 | 0.0737 |
Trypanosoma brucei | histone deacetylase 1 | 0.0931 | 0.2699 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0889 | 0.2481 | 0.8891 |
Trypanosoma brucei | histone deacetylase 3 | 0.0889 | 0.2481 | 0.8891 |
Echinococcus granulosus | histone deacetylase 7 | 0.0889 | 0.2481 | 0.1883 |
Brugia malayi | Histone deacetylase 1 | 0.0931 | 0.2699 | 0.2118 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0931 | 0.2699 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0931 | 0.2699 | 0.5 |
Echinococcus granulosus | histone deacetylase 3 | 0.0931 | 0.2699 | 0.2118 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0889 | 0.2481 | 0.8891 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0931 | 0.2699 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0931 | 0.2699 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0889 | 0.2481 | 0.8891 |
Plasmodium vivax | histone deacetylase, putative | 0.0889 | 0.2481 | 0.8891 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 222 % | Percentage opening of human Maxi-K channel in transfected oocyte cells at 5 uM | ChEMBL. | 15380205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.