Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | epidermal growth factor receptor | 0.042 | 0.3945 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0782 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0496 | 0.5212 | 0.4623 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.1602 | 0.0568 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.025 | 0.1096 | 0.0145 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0496 | 0.5212 | 0.4623 |
Schistosoma mansoni | tyrosine kinase | 0.0416 | 0.3871 | 0.3452 |
Schistosoma mansoni | tyrosine kinase | 0.0416 | 0.3871 | 0.3452 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.042 | 0.3945 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.025 | 0.1096 | 0.0486 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.3242 | 0.241 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0496 | 0.5212 | 0.4623 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0496 | 0.5212 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.042 | 0.3945 | 0.3531 |
Leishmania major | 0.0496 | 0.5212 | 0.5 | |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0496 | 0.5212 | 0.4884 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.042 | 0.3945 | 0.3299 |
Schistosoma mansoni | tyrosine kinase | 0.0416 | 0.3871 | 0.3452 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0496 | 0.5212 | 1 |
Echinococcus multilocularis | insulin receptor | 0.025 | 0.1096 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.042 | 0.3945 | 0.3531 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0496 | 0.5212 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0782 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0496 | 0.5212 | 0.4701 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0496 | 0.5212 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.3242 | 0.241 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0782 | 1 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.1602 | 0.0705 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0782 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.025 | 0.1096 | 0.0486 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.