Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase | 0.1519 | 0.9089 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1589 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1088 | 0.3513 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1088 | 0.3513 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1088 | 0.3513 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1088 | 0.3513 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1519 | 0.9089 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.095 | 0.1732 | 0.6554 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1021 | 0.2642 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1088 | 0.3513 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1088 | 0.3513 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1088 | 0.3513 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1088 | 0.3513 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1519 | 0.9089 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1519 | 0.9089 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1589 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1088 | 0.3513 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 5100 ng ml-1 | Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38 | ChEMBL. | 15955697 |
EC50 (functional) | = 5100 ng ml-1 | Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38 | ChEMBL. | 15955697 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.