Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0497 | 0.5164 | 0.4558 |
Schistosoma mansoni | tyrosine kinase | 0.0419 | 0.3884 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0419 | 0.3884 | 0.3117 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0497 | 0.5164 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0252 | 0.1115 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0424 | 0.3958 | 0.32 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0424 | 0.3958 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0789 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0497 | 0.5164 | 0.4558 |
Schistosoma mansoni | tyrosine kinase | 0.0419 | 0.3884 | 0.3117 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0497 | 0.5164 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0497 | 0.5164 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0789 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0497 | 0.5164 | 0.4637 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0424 | 0.3958 | 0.3299 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0497 | 0.5164 | 0.4558 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0789 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0252 | 0.1115 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0789 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0497 | 0.5164 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0497 | 0.5164 | 0.4558 |
Leishmania major | 0.0497 | 0.5164 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0424 | 0.3958 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0424 | 0.3958 | 0.32 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.9 nM | Inhibition of [3H]-dexamethasone binding to glucocorticoid receptor | ChEMBL. | 15261264 |
IC50 (binding) | = 3.9 nM | Inhibition of [3H]-dexamethasone binding to glucocorticoid receptor | ChEMBL. | 15261264 |
IC50 (functional) | = 640 nM | Inhibition of glucocorticoid receptor dexamethasone response | ChEMBL. | 15261264 |
IC50 (functional) | = 640 nM | Inhibition of glucocorticoid receptor dexamethasone response | ChEMBL. | 15261264 |
T1/2 (ADMET) | 0 min | Half-life of the compound was determined in rat microsomes; not determined | ChEMBL. | 15261264 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.