Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.1703 | 0.1639 |
Leishmania major | 0.0492 | 1 | 0.5 | |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0164 | 0.1747 | 0.1683 |
Schistosoma mansoni | tyrosine kinase | 0.0305 | 0.5296 | 0.5259 |
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.1747 | 0.1683 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0492 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0164 | 0.1747 | 0.1747 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0164 | 0.1747 | 0.1683 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0492 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0492 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0097 | 0.0077 | 0.0077 |
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.1747 | 0.1683 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0492 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0305 | 0.5296 | 0.5259 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.1703 | 0.1639 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0492 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0097 | 0.0077 | 0.0077 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.1703 | 0.1639 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0305 | 0.5296 | 0.5259 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0305 | 0.5296 | 0.5296 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0492 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0492 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0305 | 0.5296 | 0.5259 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0492 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of human vanilloid receptor 1 in HEK293 cells in capsaicin-induced FLIPR assay | ChEMBL. | 15482915 |
IC50 (binding) | > 10000 nM | Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assay | ChEMBL. | 15482915 |
IC50 (binding) | > 10000 nM | Inhibition of human vanilloid receptor 1 in HEK293 cells in capsaicin-induced FLIPR assay | ChEMBL. | 15482915 |
IC50 (binding) | > 10000 nM | Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assay | ChEMBL. | 15482915 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.