Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0347 | 0.3299 | 0.32 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0338 | 0.3099 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0646 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0338 | 0.3099 | 0.2997 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0338 | 0.3099 | 0.2997 |
Echinococcus multilocularis | insulin receptor | 0.0206 | 0.0145 | 0.0145 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0338 | 0.3099 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0338 | 0.3099 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0347 | 0.3299 | 0.32 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0338 | 0.3099 | 0.2997 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0338 | 0.3099 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0347 | 0.3299 | 0.32 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0338 | 0.3099 | 0.3099 |
Schistosoma mansoni | tyrosine kinase | 0.0343 | 0.3217 | 0.3117 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0646 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0206 | 0.0145 | 0.0145 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0646 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0347 | 0.3299 | 0.3299 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0646 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0343 | 0.3217 | 0.3117 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0338 | 0.3099 | 0.2997 |
Schistosoma mansoni | tyrosine kinase | 0.0343 | 0.3217 | 0.3117 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0347 | 0.3299 | 0.32 |
Leishmania major | 0.0338 | 0.3099 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1 uM | Inhibition of Hepatitis C virus NS3 serine protease | ChEMBL. | 15501035 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.