Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | uridine phosphorylase | 0.1205 | 0.5 | 0.5 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.1205 | 0.5 | 0.5 |
Mycobacterium leprae | probable uridine phosphorylase | 0.1205 | 0.5 | 0.5 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.1205 | 0.5 | 0.5 |
Schistosoma mansoni | uridine phosphorylase | 0.1205 | 0.5 | 0.5 |
Loa Loa (eye worm) | uridine phosphorylase | 0.1205 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MPC8 (functional) | = 4 ug ml-1 | In vitro minimum potentiation concentration to achieve an 8-fold reduction in fluconazole MIC against Candida albicans strain YEM15 (over-expressing both CDR1 and CDR2) | ChEMBL. | 15380214 |
MPC8 (functional) | = 4 ug ml-1 | In vitro minimum potentiation concentration to achieve an 8-fold reduction in fluconazole MIC against Candida glabrata strain YEM19 (over-expressing both CgDR1 and CgDR2) | ChEMBL. | 15380214 |
MPC8 (functional) | = 4 ug ml-1 | In vitro minimum potentiation concentration to achieve an 8-fold reduction in fluconazole MIC against Candida albicans strain YEM15 (over-expressing both CDR1 and CDR2) | ChEMBL. | 15380214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.