Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0329 | 0.3217 | 0.3117 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0333 | 0.3302 | 0.3203 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0333 | 0.3302 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0198 | 0.0145 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0332 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0329 | 0.3217 | 0.3117 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0332 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0619 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0333 | 0.3302 | 0.3203 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0333 | 0.3302 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0329 | 0.3217 | 0.3117 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0619 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0619 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0198 | 0.0145 | 0.0145 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0333 | 0.3302 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0619 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0333 | 0.3302 | 0.3302 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0333 | 0.3302 | 0.3203 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0332 | 0.3299 | 0.3299 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0333 | 0.3302 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0332 | 0.3299 | 0.32 |
Leishmania major | 0.0333 | 0.3302 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0332 | 0.3299 | 0.32 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0333 | 0.3302 | 0.3203 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 33 uM | In vitro inhibitory concentration against A-FABP (Adipocyte fatty acid binding protein) | ChEMBL. | 15357970 |
IC50 (binding) | = 33 uM | In vitro inhibitory concentration against A-FABP (Adipocyte fatty acid binding protein) | ChEMBL. | 15357970 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.