Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Starlite/ChEMBL | References |
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0203 | 0.3312 | 0.3312 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.4059 | 1 |
Onchocerca volvulus | 0.0203 | 0.3312 | 1 | |
Onchocerca volvulus | 0.0203 | 0.3312 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0203 | 0.3312 | 0.3312 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.2605 | 0.2605 |
Onchocerca volvulus | 0.0203 | 0.3312 | 1 | |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 1 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.6255 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.014 | 0.0887 | 0.0887 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0887 | 0.0887 |
Onchocerca volvulus | 0.0203 | 0.3312 | 1 | |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.6425 | 0.6425 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1089 | 0.1089 |
Onchocerca volvulus | 0.0203 | 0.3312 | 1 | |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.6255 | 1 |
Onchocerca volvulus | 0.0203 | 0.3312 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0203 | 0.3312 | 0.3312 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.3312 | 0.3312 |
Onchocerca volvulus | 0.0203 | 0.3312 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0203 | 0.3312 | 0.3312 |
Onchocerca volvulus | 0.0203 | 0.3312 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 nM | In vitro inhibitory activity against alpha v beta 3 vitronectin protein interaction was measured by ELISA | ChEMBL. | 15357991 |
IC50 (binding) | = 100 nM | In vitro inhibitory activity against alpha v beta 3 vitronectin protein interaction was measured by ELISA | ChEMBL. | 15357991 |
IC50 (binding) | = 170 nM | In vitro inhibitory activity against alpha IIb beta IIIa fibrinogen protein interaction was measured by ELISA | ChEMBL. | 15357991 |
IC50 (binding) | = 170 nM | In vitro inhibitory activity against alpha IIb beta IIIa fibrinogen protein interaction was measured by ELISA | ChEMBL. | 15357991 |
IC50 (binding) | > 20000 nM | In vitro inhibitory activity against alpha 5 beta 1 fibronectin protein interaction was measured by ELISA | ChEMBL. | 15357991 |
IC50 (binding) | > 20000 nM | In vitro inhibitory activity against alpha v beta 5 vitronectin protein interaction was measured by ELISA | ChEMBL. | 15357991 |
IC50 (binding) | > 20000 nM | In vitro inhibitory activity against alpha 5 beta 1 fibronectin protein interaction was measured by ELISA | ChEMBL. | 15357991 |
IC50 (binding) | > 20000 nM | In vitro inhibitory activity against alpha v beta 5 vitronectin protein interaction was measured by ELISA | ChEMBL. | 15357991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.