Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0336 | 0.3403 | 0.7429 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0125 | 0.113 | 0.113 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0015 | 0.0035 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0065 | 0.0482 | 0.1876 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0064 | 0.0473 | 0.1033 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0125 | 0.113 | 0.2734 |
Brugia malayi | Protein kinase domain containing protein | 0.012 | 0.1071 | 0.2593 |
Trypanosoma brucei | RNA helicase, putative | 0.095 | 1 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0022 | 0.0015 | 0.0032 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0076 | 0.06 | 0.06 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0125 | 0.113 | 0.2466 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0473 | 0.1146 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0189 | 0.182 | 0.3973 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0022 | 0.0015 | 0.0032 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0125 | 0.113 | 0.2466 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0022 | 0.0015 | 0.0032 |
Trypanosoma brucei | ribonuclease H1 | 0.0253 | 0.2508 | 0.2497 |
Schistosoma mansoni | phosphoglucomutase | 0.0253 | 0.2508 | 0.2508 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0064 | 0.0473 | 0.1146 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.085 | 0.2057 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0253 | 0.2508 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0189 | 0.182 | 0.3973 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.007 | 0.0532 | 0.1286 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0064 | 0.0473 | 0.1033 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0022 | 0.0015 | 0.0032 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.085 | 0.2057 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Brugia malayi | reverse transcriptase | 0.0022 | 0.0015 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0473 | 0.1146 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0121 | 0.0121 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0064 | 0.0473 | 0.184 |
Schistosoma mansoni | phosphoglucomutase | 0.0253 | 0.2508 | 0.2508 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0065 | 0.0479 | 0.1863 |
Brugia malayi | Zinc knuckle family protein | 0.0022 | 0.0015 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.113 | 0.113 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0125 | 0.113 | 0.2466 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0473 | 0.1146 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0321 | 0.3234 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0253 | 0.2508 | 0.5474 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0065 | 0.0479 | 0.1046 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0253 | 0.2508 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0321 | 0.3234 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0022 | 0.0015 | 0.0032 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0479 | 0.0479 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0189 | 0.182 | 0.3973 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0253 | 0.2508 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0189 | 0.182 | 0.3973 |
Brugia malayi | reverse transcriptase | 0.0022 | 0.0015 | 0.0035 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.007 | 0.0532 | 0.1286 |
Schistosoma mansoni | protein kinase | 0.0022 | 0.0015 | 0.0015 |
Brugia malayi | Zinc knuckle family protein | 0.0022 | 0.0015 | 0.0035 |
Giardia lamblia | Ribonuclease H | 0.0253 | 0.2508 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0321 | 0.3234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.088 | 0.2129 |
Schistosoma mansoni | glutamate receptor kainate | 0.0125 | 0.113 | 0.113 |
Brugia malayi | RNase H family protein | 0.0253 | 0.2508 | 0.6068 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0121 | 0.0121 |
Leishmania major | ribonuclease H1, putative | 0.0253 | 0.2508 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0022 | 0.0015 | 0.0032 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0121 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.4132 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0121 | 0.0121 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0022 | 0.0015 | 0.0032 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0022 | 0.0015 | 0.0032 |
Schistosoma mansoni | protein kinase | 0.0065 | 0.0479 | 0.0479 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0121 | 0.0292 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0022 | 0.0015 | 0.0032 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0064 | 0.0473 | 0.1146 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0479 | 0.116 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0513 | 0.124 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0125 | 0.113 | 0.2466 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0446 | 0.4581 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0189 | 0.182 | 0.3973 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0189 | 0.182 | 0.182 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0022 | 0.0015 | 0.0032 |
Echinococcus granulosus | glutamate receptor 2 | 0.0064 | 0.0473 | 0.1033 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0115 | 0.1019 | 0.2224 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0115 | 0.1019 | 0.2224 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0446 | 0.4581 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0125 | 0.113 | 0.2734 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0336 | 0.3403 | 0.7429 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0065 | 0.0479 | 0.116 |
Schistosoma mansoni | glutamate receptor kainate | 0.0125 | 0.113 | 0.113 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0121 | 0.0292 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0446 | 0.4581 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0321 | 0.3234 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0064 | 0.0473 | 0.1033 |
Brugia malayi | reverse transcriptase | 0.0022 | 0.0015 | 0.0035 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0064 | 0.0473 | 0.1146 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0513 | 0.124 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0121 | 0.0121 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0125 | 0.113 | 0.2466 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0015 | 0.0035 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0065 | 0.0479 | 0.116 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0912 | 0.2206 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0189 | 0.182 | 0.3973 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0125 | 0.113 | 0.2734 |
Brugia malayi | RNase H family protein | 0.0253 | 0.2508 | 0.6068 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0275 | 0.2739 | 0.2728 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0121 | 0.0264 |
Entamoeba histolytica | hypothetical protein | 0.0064 | 0.0473 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0125 | 0.113 | 0.2466 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0064 | 0.0473 | 0.1033 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0125 | 0.113 | 0.2734 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0275 | 0.2739 | 0.2728 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0064 | 0.0473 | 0.1146 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0065 | 0.0479 | 0.116 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0253 | 0.2508 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0065 | 0.0482 | 0.1876 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0121 | 0.0292 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.012 | 0.1071 | 0.2592 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0065 | 0.0479 | 0.1046 |
Onchocerca volvulus | 0.0065 | 0.0479 | 0.1863 | |
Brugia malayi | RNase H family protein | 0.0253 | 0.2508 | 0.6068 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.007 | 0.0532 | 0.116 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0064 | 0.0473 | 0.1146 |
Trypanosoma brucei | unspecified product | 0.0275 | 0.2739 | 0.2728 |
Schistosoma mansoni | scy1(yeast) protein kinase-like | 0.0022 | 0.0015 | 0.0015 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0064 | 0.0473 | 0.1146 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0121 | 0.0264 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0064 | 0.0473 | 0.1033 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0064 | 0.0473 | 0.1033 |
Echinococcus granulosus | tyrosine kinase | 0.0065 | 0.0479 | 0.1046 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0321 | 0.3234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0473 | 0.1146 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0065 | 0.0479 | 0.116 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0121 | 0.0292 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0064 | 0.0473 | 0.1033 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.007 | 0.0532 | 0.116 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0022 | 0.0015 | 0.0032 |
Echinococcus multilocularis | ribonuclease H1 | 0.0253 | 0.2508 | 0.5474 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0065 | 0.0479 | 0.116 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0125 | 0.113 | 0.2466 |
Echinococcus multilocularis | NMDA receptor | 0.0125 | 0.113 | 0.2466 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0433 | 0.1047 |
Echinococcus multilocularis | tyrosine kinase | 0.0065 | 0.0479 | 0.1046 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0022 | 0.0015 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0473 | 0.1146 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0473 | 0.1146 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0064 | 0.0473 | 0.1146 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0015 | 0.0015 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0022 | 0.0015 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0473 | 0.1146 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Schistosoma mansoni | phosphoglucomutase | 0.0253 | 0.2508 | 0.2508 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0189 | 0.182 | 0.3973 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0473 | 0.1146 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0022 | 0.0015 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.098 | 0.2372 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0189 | 0.182 | 0.3973 |
Schistosoma mansoni | glutamate receptor kainate | 0.0125 | 0.113 | 0.113 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0513 | 0.0513 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0064 | 0.0473 | 0.0473 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0115 | 0.1019 | 0.2466 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0321 | 0.3234 | 0.5 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0479 | 0.0479 |
Onchocerca volvulus | 0.0064 | 0.0473 | 0.184 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0404 | 0.4132 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0121 | 0.0264 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0125 | 0.113 | 0.2466 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0275 | 0.2739 | 0.2728 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0015 | 0.0035 |
Echinococcus granulosus | KRAB A domain containing protein | 0.0022 | 0.0015 | 0.0032 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0125 | 0.113 | 0.2466 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0253 | 0.2508 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0275 | 0.2739 | 0.2728 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0125 | 0.113 | 0.113 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0064 | 0.0473 | 0.1033 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0064 | 0.0473 | 0.0473 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0189 | 0.182 | 0.3973 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0022 | 0.0015 | 0.0035 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0125 | 0.113 | 0.113 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0022 | 0.0015 | 0.0015 |
Brugia malayi | hypothetical protein | 0.0064 | 0.0473 | 0.1146 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0125 | 0.113 | 0.113 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0125 | 0.113 | 0.2466 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0022 | 0.0015 | 0.0032 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0015 | 0.0035 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0076 | 0.06 | 0.06 |
Toxoplasma gondii | ribonuclease HI protein | 0.0253 | 0.2508 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0015 | 0.0015 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0189 | 0.182 | 0.3973 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0022 | 0.0015 | 0.0032 |
Loa Loa (eye worm) | glutamate receptor | 0.0064 | 0.0473 | 0.1146 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0064 | 0.0473 | 0.1033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 275 % | Percentage of protein-linked DNA breaks in KB cells by [3H]-thymidine incorporation at 5 ug/mL | ChEMBL. | 15456257 |
Activity (functional) | = 275 % | Percentage of protein-linked DNA breaks in KB cells by [3H]-thymidine incorporation at 5 ug/mL | ChEMBL. | 15456257 |
Activity (functional) | = 368 % | Percentage of protein-linked DNA breaks in KB cells by [3H]-thymidine incorporation | ChEMBL. | 15456257 |
Activity (functional) | = 368 % | Percentage of protein-linked DNA breaks in KB cells by [3H]-thymidine incorporation | ChEMBL. | 15456257 |
ED50 (functional) | = 0.02 ug ml-1 | Dose required to cause reduction in human nasopharyngeal KB cancer cells after 3 days incubation | ChEMBL. | 15456257 |
ED50 (functional) | = 0.02 ug ml-1 | Dose required to cause reduction in human nasopharyngeal KB cancer cells after 3 days incubation | ChEMBL. | 15456257 |
ED50 (functional) | = 0.8 ug ml-1 | Dose required for reduction in human nasopharyngeal KB-7d cancer cells after 3 days incubation | ChEMBL. | 15456257 |
ED50 (functional) | = 0.8 ug ml-1 | Dose required for reduction in human nasopharyngeal KB-7d cancer cells after 3 days incubation | ChEMBL. | 15456257 |
Relative resistance (functional) | = 32 | Ratio of ED50 for KB-7d cells to that of KB cells | ChEMBL. | 15456257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.