Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.026 | 0.3827 | 0.3117 |
Echinococcus multilocularis | insulin receptor | 0.0156 | 0.1032 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0263 | 0.3902 | 0.32 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0317 | 0.5369 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0317 | 0.5369 | 0.4836 |
Schistosoma mansoni | tyrosine kinase | 0.026 | 0.3827 | 0.3117 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0317 | 0.5369 | 0.4836 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0263 | 0.3902 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0489 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0263 | 0.3902 | 0.3299 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0317 | 0.5369 | 0.4836 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0317 | 0.5369 | 0.4911 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0489 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0317 | 0.5369 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0156 | 0.1032 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0489 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0489 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.026 | 0.3827 | 0.3117 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0317 | 0.5369 | 1 |
Leishmania major | 0.0317 | 0.5369 | 0.5 | |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0317 | 0.5369 | 0.4836 |
Schistosoma mansoni | tyrosine kinase | 0.0263 | 0.3902 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0263 | 0.3902 | 0.32 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0317 | 0.5369 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 18 ug ml-1 | Minimum inhibitory concentration required for antibacterial activity against Staphylococcus aureus ATCC 2943; gram positive | ChEMBL. | 15261267 |
MIC (functional) | = 21 ug ml-1 | Minimum inhibitory concentration required for antibacterial activity against Bacillus subtilis ATCC 6633; gram positive | ChEMBL. | 15261267 |
MIC (functional) | = 22 ug ml-1 | Minimum inhibitory concentration required for antibacterial activity against Escherichia coli ATCC 13607; gram negative | ChEMBL. | 15261267 |
MIC (functional) | = 22 ug ml-1 | Minimum inhibitory concentration required for antibacterial activity against Escherichia coli ATCC 13607; gram negative | ChEMBL. | 15261267 |
MIC (functional) | = 25 ug ml-1 | Minimum inhibitory concentration required for antibacterial activity against Pseudomonas diminuta MTCC 3361; gram negative | ChEMBL. | 15261267 |
MIC (functional) | = 35 ug ml-1 | Minimum inhibitory concentration required for antifungal activity against Candida albicans ATCC 10321 | ChEMBL. | 15261267 |
MIC (functional) | = 35 ug ml-1 | Minimum inhibitory concentration required for antifungal activity against Candida albicans ATCC 10321 | ChEMBL. | 15261267 |
MIC (functional) | = 39 ug ml-1 | Minimum inhibitory concentration required for antifungal activity against Aspergillus niger ATCC 16404 | ChEMBL. | 15261267 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.