Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aldehyde dehydrogenase | 0.0041 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.003 | 0.615 | 0.615 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0041 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.003 | 0.615 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.003 | 0.615 | 0.615 |
Giardia lamblia | DINP protein human, muc B family | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0041 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.003 | 0.615 | 0.615 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0041 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 0.2937 | 0.2937 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.615 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.003 | 0.615 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0013 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0041 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0041 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.003 | 0.615 | 0.615 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.2937 | 0.4775 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0041 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0041 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.003 | 0.615 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0041 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0013 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus (strain A15090) in presence of 50% calf serum | ChEMBL. | 15324898 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration against methicillin resistant Staphylococcus aureus (strain A27223) in presence of 50% calf serum | ChEMBL. | 15324898 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration against Enterococcus faecalis (strain A20688) in presence of 50% calf serum | ChEMBL. | 15324898 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration against Haemophilus influenzae (strain A20191) in absence of calf serum | ChEMBL. | 15324898 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus (strain A15090) in absence of calf serum | ChEMBL. | 15324898 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration against methicillin resistant Staphylococcus aureus (strain A27223) in absence of calf serum | ChEMBL. | 15324898 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration against Enterococcus faecalis (strain A20688) in absence of calf serum | ChEMBL. | 15324898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.