Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1155 | 0.1953 |
Onchocerca volvulus | 0.0053 | 0.1155 | 0.2203 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1886 | 0.319 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.4771 | 0.8068 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0053 | 0.1155 | 0.1953 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.4771 | 0.7599 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0117 | 0.5242 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0064 | 0.1886 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1155 | 0.1953 |
Brugia malayi | Hemopexin family protein | 0.0075 | 0.2557 | 0.2947 |
Loa Loa (eye worm) | matrixin family protein | 0.0127 | 0.5913 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0064 | 0.1886 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0117 | 0.5242 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0053 | 0.1155 | 0.2203 |
Brugia malayi | Matrixin family protein | 0.0127 | 0.5913 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1155 | 0.1953 |
Loa Loa (eye worm) | matrixin family protein | 0.0117 | 0.5242 | 0.8865 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0053 | 0.1155 | 0.2404 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0064 | 0.1886 | 0.1537 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.2557 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0064 | 0.1886 | 0.5 |
Onchocerca volvulus | 0.0075 | 0.2557 | 0.4878 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21 nM | Inhibitory concentration against matrix metalloproteinase 13 | ChEMBL. | 15324896 |
IC50 (binding) | = 21 nM | Inhibitory concentration against matrix metalloproteinase 13 | ChEMBL. | 15324896 |
IC50 (binding) | = 55 nM | Inhibitory concentration against aggrecanase | ChEMBL. | 15324896 |
IC50 (binding) | = 55 nM | Inhibitory concentration against aggrecanase | ChEMBL. | 15324896 |
IC50 (binding) | = 12000 nM | Inhibitory concentration against matrix metalloproteinase 1 | ChEMBL. | 15324896 |
IC50 (binding) | = 12000 nM | Inhibitory concentration against matrix metalloproteinase 1 | ChEMBL. | 15324896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.