Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 23.59 | Cytotoxicity against VERO cells (CCL-81) | ChEMBL. | 15456272 |
IC50 (binding) | = 62 ug ml-1 | Inhibition of M. tuberculosis UDP-galactose mutase expressed in E. coli UDP-6 [3H]- Galf | ChEMBL. | 15456272 |
IC50 (binding) | = 62 ug ml-1 | Inhibition of M. tuberculosis UDP-galactose mutase expressed in E. coli UDP-6 [3H]- Galf | ChEMBL. | 15456272 |
Protein binding (ADMET) | = 65.57 % | The protein binding is expressed as percent bound as determined by VolSurf | ChEMBL. | 15456272 |
Selectivity index (functional) | = 29.5 | Selectivity is the ratio of cytotoxicity compared to TBMIC | ChEMBL. | 15456272 |
TBMIC (functional) | = 0.8 ug ml-1 | Activity against M. tuberculosis H37Ra | ChEMBL. | 15456272 |
TBMIC (functional) | = 0.8 ug ml-1 | Activity against M. tuberculosis H37Ra | ChEMBL. | 15456272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.