Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1358 | 1 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1358 | 1 | 0.5 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1358 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1358 | 1 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1358 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1358 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.084 | 0.6017 | 0.5928 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0218 | 0.0218 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1358 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1358 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0426 | 0.283 | 0.2671 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1358 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1358 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1358 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.084 | 0.6017 | 0.5928 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1358 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1358 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1358 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0087 | 0.0218 | 0.5 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1358 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.084 | 0.6017 | 0.5928 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1358 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1358 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1358 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0087 | 0.0218 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.084 | 0.6017 | 0.5928 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of human vanilloid receptor 1 in HEK293 cells in capsaicin-induced FLIPR assay | ChEMBL. | 15482915 |
IC50 (binding) | > 10000 nM | Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assay | ChEMBL. | 15482915 |
IC50 (binding) | > 10000 nM | Inhibition of human vanilloid receptor 1 in HEK293 cells in capsaicin-induced FLIPR assay | ChEMBL. | 15482915 |
IC50 (binding) | > 10000 nM | Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assay | ChEMBL. | 15482915 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.