Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0513 | 0.3983 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0513 | 0.3983 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1238 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0124 | 0.0753 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0513 | 0.3983 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.049 | 0.379 | 0.3344 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0124 | 0.0753 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0124 | 0.0753 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0263 | 0.1906 | 0.031 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0124 | 0.0753 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0124 | 0.0753 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0513 | 0.3983 | 0.3983 |
Plasmodium falciparum | inorganic anion exchanger, inorganic anion antiporter | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0513 | 0.3983 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0124 | 0.0753 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0124 | 0.0753 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0124 | 0.0753 | 1 |
Toxoplasma gondii | inorganic anion transporter, sulfate permease (SulP) family protein | 0.0033 | 0 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0207 | 0.1447 | 0.5 |
Onchocerca volvulus | 0.0207 | 0.1447 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.1238 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0124 | 0.0753 | 1 |
Chlamydia trachomatis | sulfate transporter | 0.0033 | 0 | 0.5 |
Plasmodium vivax | sulfate transporter, putative | 0.0033 | 0 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0988 | 0.7923 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.4 nM | Binding affinity for Norepinephrine transporter | ChEMBL. | 15454233 |
Ki (binding) | = 1.5 nM | Binding affinity for 5-hydroxytryptamine transporter | ChEMBL. | 15454233 |
Ki (binding) | = 120 nM | Binding affinity for Dopamine transporter | ChEMBL. | 15454233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.