Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0181 | 0.0802 | 0.4279 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.1131 | 1 | 1 |
Echinococcus granulosus | Ankyrin | 0.0098 | 0.0005 | 0.0005 |
Brugia malayi | bZIP transcription factor family protein | 0.0359 | 0.2526 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0181 | 0.0802 | 0.3176 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0181 | 0.0802 | 0.4279 |
Echinococcus multilocularis | jun protein | 0.0359 | 0.2526 | 0.2526 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0181 | 0.0802 | 0.3287 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.243 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0098 | 0.0005 | 0.0005 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0098 | 0.0005 | 0.0027 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0181 | 0.0802 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0181 | 0.0802 | 0.5 |
Brugia malayi | hypothetical protein | 0.0282 | 0.178 | 0.7047 |
Echinococcus granulosus | carbonic anhydrase II | 0.0181 | 0.0802 | 0.0802 |
Schistosoma mansoni | hypothetical protein | 0.0292 | 0.1875 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0181 | 0.0802 | 0.0802 |
Leishmania major | carbonic anhydrase-like protein | 0.0181 | 0.0802 | 0.5 |
Onchocerca volvulus | 0.0282 | 0.178 | 0.5 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0181 | 0.0802 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0181 | 0.0802 | 0.3287 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0181 | 0.0802 | 0.3176 |
Echinococcus granulosus | jun protein | 0.0359 | 0.2526 | 0.2526 |
Schistosoma mansoni | jun-related protein | 0.0292 | 0.1875 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0359 | 0.2526 | 0.2526 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0359 | 0.2526 | 0.2526 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5 nM | Inhibitory activity against human Carbonic anhydrase II | ChEMBL. | 15456265 |
Ki (binding) | = 5 nM | Inhibitory activity against human Carbonic anhydrase II | ChEMBL. | 15456265 |
Ki (binding) | = 31 nM | Inhibitory activity against human Carbonic anhydrase I | ChEMBL. | 15456265 |
Ki (binding) | = 31 nM | Inhibitory activity against human Carbonic anhydrase I | ChEMBL. | 15456265 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.