Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0089 | 0.1531 | 0.6515 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0399 | 0.0133 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0391 | 1 | 1 |
Brugia malayi | proprotein convertase 2 | 0.0092 | 0.1616 | 0.1383 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0092 | 0.1616 | 0.1383 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0089 | 0.1531 | 0.1531 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.0176 | 0.0559 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0391 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0715 | 0.2274 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0167 | 0.3708 | 0.3708 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0092 | 0.1616 | 0.5135 |
Brugia malayi | celfurPC protein | 0.0118 | 0.235 | 0.2138 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.0176 | 0.0749 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0391 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0176 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.3146 | 0.3146 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0715 | 0.3045 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0147 | 0.3146 | 0.3146 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0391 | 1 | 0.5 |
Brugia malayi | endoprotease bli-4 precursor | 0.0147 | 0.3146 | 0.2956 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0391 | 1 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0391 | 1 | 0.5 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0391 | 1 | 0.5 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.0399 | 0.0399 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0587 | 0.1864 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0167 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0089 | 0.1531 | 0.1531 |
Echinococcus granulosus | furin | 0.0147 | 0.3146 | 1 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0147 | 0.3146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0643 | 0.0643 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0391 | 1 | 0.5 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0089 | 0.1531 | 0.4865 |
Echinococcus multilocularis | 0.0118 | 0.235 | 1 | |
Schistosoma mansoni | furin-1 (S08 family) | 0.0064 | 0.0819 | 0.2603 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0391 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0715 | 0.0715 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0092 | 0.1616 | 0.6877 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 39 nM | Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist | ChEMBL. | 15482907 |
IC50 (functional) | = 39 nM | Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist | ChEMBL. | 15482907 |
Ki (binding) | = 95 nM | Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes | ChEMBL. | 15482907 |
Ki (binding) | = 95 nM | Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes | ChEMBL. | 15482907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.