Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholesteryl ester transfer protein, plasma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0529 | 0.3235 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1225 | 0.785 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0529 | 0.3235 | 0.3841 |
Onchocerca volvulus | 0.0259 | 0.1448 | 0.9143 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.0357 | 0.0455 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0529 | 0.3235 | 0.4121 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1204 | 0.7717 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0918 | 0.0748 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1225 | 0.785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0529 | 0.3235 | 0.4121 |
Loa Loa (eye worm) | hypothetical protein | 0.0529 | 0.3235 | 0.4121 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1225 | 0.785 | 0.5 |
Echinococcus granulosus | geminin | 0.0179 | 0.0918 | 0.0748 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.1584 | 0.2017 |
Echinococcus granulosus | carbonic anhydrase II | 0.1225 | 0.785 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0529 | 0.3235 | 0.3841 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1028 | 0.6546 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0529 | 0.3235 | 0.4121 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0529 | 0.3235 | 0.3841 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0529 | 0.3235 | 0.4121 |
Echinococcus multilocularis | geminin | 0.0179 | 0.0918 | 0.0748 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1549 | 1 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0529 | 0.3235 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0529 | 0.3235 | 0.4121 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.0357 | 0.0455 |
Echinococcus multilocularis | carbonic anhydrase | 0.0529 | 0.3235 | 0.3841 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0529 | 0.3235 | 0.4121 |
Schistosoma mansoni | carbonic anhydrase | 0.0529 | 0.3235 | 0.3841 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1225 | 0.785 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0529 | 0.3235 | 0.3841 |
Echinococcus multilocularis | carbonic anhydrase | 0.0529 | 0.3235 | 0.3841 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0279 | 0.1584 | 0.1637 |
Onchocerca volvulus | 0.0279 | 0.1584 | 1 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0529 | 0.3235 | 0.4121 |
Brugia malayi | Trypsin family protein | 0.0279 | 0.1584 | 0.2017 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1225 | 0.785 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0529 | 0.3235 | 0.3841 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1225 | 0.785 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.1584 | 0.2017 |
Echinococcus multilocularis | carbonic anhydrase | 0.0529 | 0.3235 | 0.3841 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0529 | 0.3235 | 0.4121 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0684 | 0.4263 | 0.321 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0279 | 0.1584 | 0.1637 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1225 | 0.785 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1204 | 0.7717 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.1225 | 0.785 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0918 | 0.0748 |
Schistosoma mansoni | carbonic anhydrase | 0.1204 | 0.7717 | 0.9822 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0529 | 0.3235 | 0.3841 |
Echinococcus granulosus | carbonic anhydrase | 0.0529 | 0.3235 | 0.3841 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1549 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1225 | 0.785 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1225 | 0.785 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1225 | 0.785 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.4 uM | Inhibitory concentration against Cholesterol ester transfer protein (CETP) in CETP fluorescence assay | ChEMBL. | 15975789 |
IC50 (binding) | = 0.4 uM | Inhibitory concentration against Cholesterol ester transfer protein (CETP) in CETP fluorescence assay | ChEMBL. | 15975789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.