Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | adenosine deaminase, putative | 0.0823 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0823 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0823 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0823 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0823 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0823 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0823 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0823 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0823 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0823 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0823 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0823 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0823 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0823 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0823 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0823 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0823 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0823 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 3.5 ng ml-1 | Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38 | ChEMBL. | 15955697 |
EC50 (functional) | = 3.5 ng ml-1 | Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38 | ChEMBL. | 15955697 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.