Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Schistosoma japonicum | expressed protein | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.0482 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0482 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0482 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0482 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0482 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0482 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0482 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0482 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0482 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0482 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0482 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0482 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0482 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0482 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0482 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0482 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 171 % | Inhibition of PrPC polymerization by PrP-res at 100 uM | ChEMBL. | 15481988 |
Control (functional) | = 171 % | Inhibition of PrPC polymerization by PrP-res at 100 uM | ChEMBL. | 15481988 |
IC50 (binding) | = 18.54 uM | Inhibition of PTP1B (unknown origin) using pNPP as substrate | ChEMBL. | 24684845 |
Inhibition (functional) | -ve 0 | Inhibition of PrP-res formation in SMB (Scrapie mouse brain) cells at 10 uM | ChEMBL. | 15481988 |
Inhibition (binding) | = 62.75 % | Inhibition of PTP1B (unknown origin) using pNPP as substrate at 20 ug/ml | ChEMBL. | 24684845 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.