Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0353 | 0.1096 | 0.0974 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1249 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0465 | 0.152 | 0.1249 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0956 | 0.3381 | 0.3169 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0421 | 0.1353 | 0.1353 |
Echinococcus multilocularis | RUN | 0.0262 | 0.075 | 0.075 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0216 | 0.0575 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Brugia malayi | ribonucleotide reductase 2 | 0.0146 | 0.031 | 0.031 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.2352 | 0.8678 | 1 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0146 | 0.031 | 0.0149 |
Brugia malayi | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0216 | 0.0575 | 0.0575 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0348 | 0.1077 | 0.1052 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0956 | 0.3381 | 0.3169 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.031 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Onchocerca volvulus | 0.0113 | 0.0183 | 0.2441 | |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0348 | 0.1077 | 0.1052 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0254 | 0.0719 | 0.0422 |
Schistosoma mansoni | lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3764 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.27 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3293 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Echinococcus granulosus | RUN | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0465 | 0.152 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Schistosoma mansoni | lipoxygenase | 0.1097 | 0.3918 | 0.3918 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.367 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0124 | 0.0124 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Loa Loa (eye worm) | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Schistosoma mansoni | loxhd1 | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0262 | 0.075 | 0.0454 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.0146 | 0.031 | 0.0181 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1407 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0146 | 0.031 | 0.0149 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0216 | 0.0575 | 0.0575 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0452 | 0.0452 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0465 | 0.152 | 0.1249 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0124 | 0.0124 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.018 | 0.0439 | 0.0309 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Echinococcus multilocularis | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Schistosoma mansoni | polycystin 1-related | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | integrin beta-2 | 0.0303 | 0.0906 | 0.0906 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.002 | 0.002 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0956 | 0.3381 | 0.3764 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0134 | 0.0134 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Chlamydia trachomatis | transcriptional repressor NrdR | 0.0348 | 0.1077 | 0.0958 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.002 | 0.002 |
Mycobacterium leprae | conserved hypothetical protein | 0.0348 | 0.1077 | 0.1052 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.27 | 1 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0353 | 0.1096 | 0.0811 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0303 | 0.0906 | 0.0906 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0216 | 0.0575 | 0.0273 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0721 | 0.2492 | 0.2252 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.018 | 0.0439 | 0.0309 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0124 | 0.0124 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0124 | 0.0124 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0465 | 0.152 | 0.1574 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Schistosoma mansoni | DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Leishmania major | DNA topoisomerase ii | 0.018 | 0.0439 | 0.0133 |
Echinococcus granulosus | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0146 | 0.031 | 0.031 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0216 | 0.0575 | 0.0575 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0328 | 0.0999 | 0.088 |
Brugia malayi | Doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Brugia malayi | hypothetical protein | 0.007 | 0.002 | 0.002 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3169 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.0432 | 0.0432 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1574 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0456 | 0.1483 | 0.153 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.2352 | 0.8678 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0137 | 0.0276 | 0.0109 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0956 | 0.3381 | 0.3169 |
Giardia lamblia | DNA topoisomerase II | 0.02 | 0.0515 | 0.5 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.2352 | 0.8678 | 1 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0184 | 0.0452 | 0.0452 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0146 | 0.031 | 0.0178 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0845 | 0.2963 | 0.3272 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.0358 | 0.0049 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.27 | 1 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0216 | 0.0575 | 0.766 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 0.0273 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.002 | 0.002 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0227 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.002 | 0.002 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0262 | 0.075 | 0.0454 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.11 mM | Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells | ChEMBL. | 15974593 |
Ki (binding) | = 0.11 nM | Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells | ChEMBL. | 15974593 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.