Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin F (C01 family) | 0.0353 | 0.1828 | 0.1828 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0353 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | fibroinase | 0.0353 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0388 | 0.2232 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cysteine protease | 0.0353 | 0.1828 | 0.1828 |
Brugia malayi | cathepsin L-like precursor | 0.0246 | 0.0582 | 0.0582 |
Giardia lamblia | Cathepsin B precursor | 0.0388 | 0.2232 | 0.5 |
Onchocerca volvulus | 0.0353 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0388 | 0.2232 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0353 | 0.1828 | 0.1828 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0353 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0353 | 0.1828 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.0353 | 0.1828 | 0.1323 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0353 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0246 | 0.0582 | 0.0582 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0353 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | ctsf protein | 0.0353 | 0.1828 | 0.1323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0353 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0353 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin b | 0.1055 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0246 | 0.0582 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0353 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | cathepsin B | 0.0388 | 0.2232 | 0.1752 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0353 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0388 | 0.2232 | 0.2232 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0353 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0353 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0353 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Onchocerca volvulus | Cathepsin F homolog | 0.0353 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0353 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine protease, putative | 0.0353 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0353 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0388 | 0.2232 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0353 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 0.0582 | 0.2606 |
Plasmodium vivax | vivapain-2 | 0.0353 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0353 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0353 | 0.1828 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0353 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0246 | 0.0582 | 0.0582 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0353 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0353 | 0.1828 | 0.1828 |
Echinococcus multilocularis | cysteine protease | 0.0353 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0388 | 0.2232 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0353 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0353 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0353 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0353 | 0.1828 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0353 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0388 | 0.2232 | 0.5 |
Onchocerca volvulus | 0.0353 | 0.1828 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0246 | 0.0582 | 0.0582 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0353 | 0.1828 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0353 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.0246 | 0.0582 | 0.0582 |
Brugia malayi | Cathepsin L-like precursor | 0.0353 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 0.0582 | 0.2606 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1055 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0353 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0353 | 0.1828 | 0.1323 |
Brugia malayi | Cathepsin L-like precursor | 0.0246 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1055 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1055 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | hypothetical protein | 0.1055 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0353 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0353 | 0.1828 | 1 | |
Toxoplasma gondii | cathepsin B | 0.0388 | 0.2232 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0388 | 0.2232 | 0.2232 |
Echinococcus granulosus | cathepsin l1 | 0.0246 | 0.0582 | 0.0582 |
Echinococcus multilocularis | cathepsin b | 0.1055 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0353 | 0.1828 | 0.1323 |
Onchocerca volvulus | Cathepsin L homolog | 0.0353 | 0.1828 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0353 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1055 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0353 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1055 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1055 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1055 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 150 uM | Inhibitory concentration for cellular activity in jurkat assay | ChEMBL. | 15964758 |
IC50 (functional) | = 150 uM | Inhibitory concentration for cellular activity in jurkat assay | ChEMBL. | 15964758 |
k3/ki (binding) | = 110 1/m/s | Binding affinity against Caspase-6 | ChEMBL. | 15964758 |
k3/ki (binding) | = 110 1/m/s | Binding affinity against Caspase-6 | ChEMBL. | 15964758 |
k3/ki (binding) | = 276 1/m/s | Binding affinity against Caspase-8 | ChEMBL. | 15964758 |
k3/ki (binding) | = 276 1/m/s | Binding affinity against Caspase-8 | ChEMBL. | 15964758 |
k3/ki (binding) | = 280 1/m/s | Binding affinity against mouse Caspase-1 | ChEMBL. | 15964758 |
k3/ki (binding) | = 280 1/m/s | Binding affinity against mouse Caspase-1 | ChEMBL. | 15964758 |
k3/ki (binding) | = 4798 1/m/s | Binding affinity against Caspase-3 | ChEMBL. | 15964758 |
k3/ki (binding) | = 4798 1/m/s | Binding affinity against Caspase-3 | ChEMBL. | 15964758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.