Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.4 uM | Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined | ChEMBL. | 15481971 |
IC50 (binding) | = 1.4 uM | Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined | ChEMBL. | 15481971 |
IC50 (binding) | = 23 uM | Inhibitory concentration required to inhibit HIV-RT is determined | ChEMBL. | 15481971 |
IC50 (binding) | = 23 uM | Inhibitory concentration required to inhibit HIV-RT is determined | ChEMBL. | 15481971 |
IC50 (binding) | = 29 uM | Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined | ChEMBL. | 15481971 |
IC50 (binding) | = 29 uM | Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined | ChEMBL. | 15481971 |
IC50 (binding) | > 50 uM | Inhibitory concentration required to inhibit HIV-integrase is determined | ChEMBL. | 15481971 |
IC50 (binding) | > 50 uM | Inhibitory concentration required to inhibit HIV-integrase is determined | ChEMBL. | 15481971 |
IC50 (binding) | > 100 uM | Inhibitory concentration required to inhibit Klenow DNA-dependent DNA polymerase | ChEMBL. | 15481971 |
IC50 (binding) | > 100 uM | Inhibitory concentration required to inhibit Klenow DNA-dependent DNA polymerase | ChEMBL. | 15481971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.