Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Small conductance calcium-activated potassium channel | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | small conductance calcium activated potassium | Small conductance calcium-activated potassium channel | 580 aa | 475 aa | 48.0 % |
Echinococcus multilocularis | small conductance calcium activated potassium | Small conductance calcium-activated potassium channel | 580 aa | 475 aa | 48.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.1949 | 0.2145 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.746 | 0.746 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.1949 | 0.2145 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0181 | 0.9386 | 0.9386 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.1949 | 0.1949 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.1949 | 0.1949 |
Brugia malayi | RNA binding protein | 0.0069 | 0.1949 | 0.2145 |
Schistosoma mansoni | calcium-activated potassium channel | 0.019 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.1949 | 0.1949 |
Trypanosoma brucei | glucosidase, putative | 0.0039 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0176 | 0.9087 | 0.9087 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.9087 | 0.9087 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.019 | 1 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.1949 | 0.1949 |
Onchocerca volvulus | 0.0102 | 0.4163 | 0.5 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.9087 | 0.9087 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3074 | 0.3074 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3721 | 0.3721 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.1949 | 0.1949 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.1949 | 0.1949 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0176 | 0.9087 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.1949 | 0.1949 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.746 | 0.746 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.1949 | 0.1949 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.1949 | 0.1949 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0176 | 0.9087 | 0.9087 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.1949 | 0.1949 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 26 % | Displacement of [125I]-apamin from calcium-activated potassium (SK) channels of rat cortex at 10 uM | ChEMBL. | 16033276 |
Displacement (binding) | = 26 % | Displacement of [125I]-apamin from calcium-activated potassium (SK) channels of rat cortex at 10 uM | ChEMBL. | 16033276 |
IC50 (binding) | = 35.2 uM | Inhibition of [125I]-apamin binding to calcium-activated potassium (SK) channel of rat cortex | ChEMBL. | 16033276 |
IC50 (binding) | = 35.2 uM | Inhibition of [125I]-apamin binding to calcium-activated potassium (SK) channel of rat cortex | ChEMBL. | 16033276 |
Ki (binding) | = 6.8 uM | Inhibition of [125I]-apamin binding to calcium-activated potassium (SK) channel of rat cortex | ChEMBL. | 16033276 |
Ki (binding) | = 6.8 uM | Inhibition of [125I]-apamin binding to calcium-activated potassium (SK) channel of rat cortex | ChEMBL. | 16033276 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.