TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 430.451 | Formula: C22H26N2O7
H donors: 3 H acceptors: 6 LogP: 2.35 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C(C(O)C)NC(=O)c1cccc(n1)COc1cc(O)c(cc1CC)C(=O)C
InChi: 1S/C22H26N2O7/c1-5-14-9-16(12(2)25)18(27)10-19(14)31-11-15-7-6-8-17(23-15)21(28)24-20(13(3)26)22(29)30-4/h6-10,13,20,26-27H,5,11H2,1-4H3,(H,24,28)
InChiKey: LSYYLOKMIRKVDS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.8196	0.8196
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Onchocerca volvulus		0.0065	0.8317	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0023	0	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Mycobacterium ulcerans	oxidoreductase	0.0065	0.8317	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0074	1	1
Loa Loa (eye worm)	oxidoreductase	0.0065	0.8317	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	1	1
Trypanosoma cruzi	aldo-keto reductase	0.0065	0.8317	0.64
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	1	1
Echinococcus granulosus	aldo keto reductase	0.0065	0.8317	0.7946
Giardia lamblia	Aldose reductase	0.0065	0.8317	0.5
Trypanosoma cruzi	aldo/keto reductase, putative	0.0065	0.8317	0.64
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.5325	0.5325
Onchocerca volvulus		0.0065	0.8317	0.5
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0074	1	1
Schistosoma mansoni	pol-related	0.0065	0.8317	0.7946
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0065	0.8317	1
Entamoeba histolytica	aldose reductase, putative	0.0065	0.8317	0.5
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0065	0.8317	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0065	0.8317	0.7946
Mycobacterium tuberculosis	Probable oxidoreductase	0.0065	0.8317	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8317	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0065	0.8317	0.8317
Schistosoma mansoni	aldo-keto reductase	0.0065	0.8317	0.7946
Echinococcus multilocularis	aldo keto reductase	0.0065	0.8317	0.7946
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.1804	0.1804
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0065	0.8317	0.7946
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Schistosoma mansoni	aldo-keto reductase	0.0065	0.8317	0.7946
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0033	0.1804	0.1804
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0065	0.8317	0.7946
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0065	0.8317	0.8317
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Loa Loa (eye worm)	oxidoreductase	0.0065	0.8317	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0065	0.8317	0.7946
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Loa Loa (eye worm)	oxidoreductase	0.0065	0.8317	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0065	0.8317	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0065	0.8317	0.7946
Toxoplasma gondii	aldose reductase, putative	0.0065	0.8317	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.1804	0.1804
Loa Loa (eye worm)	oxidoreductase	0.0065	0.8317	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0065	0.8317	1
Echinococcus multilocularis	aldo keto reductase	0.0065	0.8317	0.7946
Onchocerca volvulus		0.0065	0.8317	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.8196	0.8196
Plasmodium falciparum	GAF domain-related protein, putative	0.0023	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1804	0.2169
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	1	1
Echinococcus granulosus	aldehyde reductase	0.0046	0.4554	0.3355
Trichomonas vaginalis	aldo/keto reductase, putative	0.0065	0.8317	0.8317
Trichomonas vaginalis	aldo/keto reductase, putative	0.0065	0.8317	0.8317
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.8196	0.8196
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.5325	0.5325
Onchocerca volvulus		0.0065	0.8317	0.5
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Onchocerca volvulus		0.0065	0.8317	0.5
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0065	0.8317	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0074	1	1
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0074	1	1
Giardia lamblia	Aldose reductase	0.0065	0.8317	0.5
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	1	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	1	1
Entamoeba histolytica	aldose reductase, putative	0.0065	0.8317	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Echinococcus granulosus	aldo keto reductase	0.0065	0.8317	0.7946
Echinococcus multilocularis	aldo keto reductase	0.0065	0.8317	0.7946
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0065	0.8317	0.8317
Echinococcus granulosus	aldo keto reductase	0.0065	0.8317	0.7946
Echinococcus granulosus	hypothetical protein	0.0065	0.8317	0.7946
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0065	0.8317	0.7946
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	1	1
Echinococcus multilocularis	aldehyde reductase	0.0046	0.4554	0.3355
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0046	0.4554	0.5475
Loa Loa (eye worm)	oxidoreductase	0.0065	0.8317	1
Entamoeba histolytica	aldose reductase, putative	0.0065	0.8317	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0065	0.8317	0.8317
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0065	0.8317	0.7946
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0065	0.8317	0.7946
Toxoplasma gondii	hypothetical protein	0.0065	0.8196	0.9855
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0065	0.8317	0.8317
Echinococcus multilocularis	aldo keto reductase	0.0065	0.8317	0.7946
Onchocerca volvulus		0.0065	0.8317	0.5
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0065	0.8317	0.7946
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0065	0.8317	0.7946
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.35 uM	Inhibitory concentration against Phosphodiesterase type 5	ChEMBL.	16005625
IC50 (binding)	= 3.35 uM	Inhibitory concentration against Phosphodiesterase type 5	ChEMBL.	16005625

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 330946