Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Yersinia pestis | Secreted effector protein | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.3 uM | Inhibitory concentration against human PTP1B expressed in Escherichia coli BL21 cells | ChEMBL. | 16039123 |
IC50 (binding) | = 4.3 uM | Inhibitory concentration against human PTP1B expressed in Escherichia coli BL21 cells | ChEMBL. | 16039123 |
IC50 (binding) | = 5.6 uM | Inhibitory concentration against Yersinia pestis YopH expressed in Escherichia coli BL21 cells | ChEMBL. | 16039123 |
IC50 (binding) | = 5.6 uM | Inhibitory concentration against Yersinia pestis YopH expressed in Escherichia coli BL21 cells | ChEMBL. | 16039123 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.