Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0246 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.3024 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0173 | 0.3024 | 0.5 | |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0246 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.3024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0246 | 1 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.3024 | 0.3024 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 0.3024 | 0.5 |
Schistosoma mansoni | amidase | 0.0246 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0246 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.3024 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.3024 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.3024 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0173 | 0.3024 | 0.3024 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.3024 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.3024 | 0.3024 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.62 | Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assay | ChEMBL. | 26584396 |
Ki (binding) | = 1 nM | Binding affinity for fatty acid amide hydrolase | ChEMBL. | 16078824 |
Ki (binding) | = 1 nM | Inhibition of rat FAAH | ChEMBL. | 18053726 |
Ki (binding) | = 1 nM | Binding affinity for fatty acid amide hydrolase | ChEMBL. | 16078824 |
Ki (binding) | = 1 nM | Inhibition of rat FAAH | ChEMBL. | 18053726 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.