Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.0127 | 0.0606 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0117 | 0.0316 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0191 | 0.2371 | 0.6156 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0213 | 0.2972 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0213 | 0.2972 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0117 | 0.0316 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.324 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.324 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0127 | 0.0606 | 0.0299 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.3852 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.0953 | 0.2474 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0191 | 0.2371 | 0.7318 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.0953 | 0.2942 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.1 nM | Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) | ChEMBL. | 15911259 |
IC50 (binding) | = 2.1 nM | Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) | ChEMBL. | 15911259 |
IC50 (binding) | = 6.2 nM | Inhibitory concentration against TNF-alpha converting enzyme | ChEMBL. | 15911259 |
IC50 (binding) | = 6.2 nM | Inhibitory concentration against TNF-alpha converting enzyme | ChEMBL. | 15911259 |
IC50 (binding) | = 145 nM | Inhibitory concentration against Aggrecanase | ChEMBL. | 15911259 |
IC50 (functional) | = 1400 nM | Inhibitory concentration against TNF-alpha release in LPS-stimulated human whole blood | ChEMBL. | 15911259 |
IC50 (functional) | = 1400 nM | Inhibitory concentration against TNF-alpha release in LPS-stimulated human whole blood | ChEMBL. | 15911259 |
IC50 (binding) | = 5100 nM | Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1) | ChEMBL. | 15911259 |
IC50 (binding) | = 5100 nM | Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1) | ChEMBL. | 15911259 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15911259 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.