Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0236 | 0.3511 | 0.147 |
Onchocerca volvulus | Matrilysin homolog | 0.0122 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0133 | 0.0337 | 0.0961 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0211 | 0.2747 | 0.0466 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0211 | 0.2747 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0236 | 0.3511 | 0.147 |
Echinococcus multilocularis | adam 17 protease | 0.0448 | 1 | 1 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0211 | 0.2747 | 0.0466 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0122 | 0 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0448 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3511 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.56 uM | Antiproliferative activity against human A549 cells by SRB assay | ChEMBL. | 24120541 |
Inhibition ratio (functional) | = 0 | Inhibition ratio against the growth of P-388 cells at 10e-8 mol/L concentration determined by MTT method | ChEMBL. | 15908202 |
Inhibition ratio (functional) | = 0 | Inhibition ratio against the growth of A-549 cells at 10e-7 mol/L concentration determined by SRB method | ChEMBL. | 15908202 |
Inhibition ratio (functional) | = 6.3 | Inhibition ratio against the growth of P-388 cells at 10e-7 mol/L concentration determined by MTT method | ChEMBL. | 15908202 |
Inhibition ratio (functional) | = 6.7 | Inhibition ratio against the growth of P-388 cells at 10e-6 mol/L concentration determined by MTT method | ChEMBL. | 15908202 |
Inhibition ratio (functional) | = 9 | Inhibition ratio against the growth of A-549 cells at 10e-8 mol/L concentration determined by SRB method | ChEMBL. | 15908202 |
Inhibition ratio (functional) | = 21.1 | Inhibition ratio against the growth of P-388 cells at 10e-5 mol/L concentration determined by MTT method | ChEMBL. | 15908202 |
Inhibition ratio (functional) | = 21.7 | Inhibition ratio against the growth of A-549 cells at 10e-6 mol/L concentration determined by SRB method | ChEMBL. | 15908202 |
Inhibition ratio (functional) | = 48.1 | Inhibition ratio against the growth of A-549 cells at 10e-5 mol/L concentration determined by SRB method | ChEMBL. | 15908202 |
Inhibition ratio (functional) | = 68 | Inhibition ratio against the growth of P-388 cells at 10e-4 mol/L concentration determined by MTT method | ChEMBL. | 15908202 |
Inhibition ratio (functional) | = 84.7 | Inhibition ratio against the growth of A-549 cells at 10e-4 mol/L concentration determined by SRB method | ChEMBL. | 15908202 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24120541 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.