Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 1.0227 | 0.401 | 0.272 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 1.0227 | 0.401 | 0.2652 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.8877 | 0.3099 | 0.1574 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.4285 | 0 | 0.5 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.8877 | 0.3099 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.4671 | 0.0261 | 0.0369 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 1.8799 | 0.9794 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.8877 | 0.3099 | 0.1534 |
Onchocerca volvulus | Matrilysin homolog | 0.4285 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.4744 | 0.7058 | 1 |
Echinococcus multilocularis | adam 17 protease | 1.8799 | 0.9794 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 5 mM | Activation of human PEPT1 expressed in MDCK cells | ChEMBL. | 16759105 |
EC50 (functional) | > 5 mM | Activation of human PEPT1 expressed in MDCK cells | ChEMBL. | 16759105 |
IC50 (functional) | = 9.16 mM | Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells | ChEMBL. | 16759105 |
IC50 (functional) | = 9.16 mM | Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells | ChEMBL. | 16759105 |
Ki (ADMET) | = -0.32 | Binding affinity to human PepT2 in SKTP cells | ChEMBL. | 21741846 |
Ki (ADMET) | = 2.1 mM | Binding affinity to human PepT2 in SKTP cells | ChEMBL. | 21741846 |
Ki (binding) | = 9.8 mM | Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells | ChEMBL. | 15974593 |
Ki (binding) | = 9.8 nM | Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells | ChEMBL. | 15974593 |
max activation (functional) | = 104 % | Activation of human PEPT1 expressed in MDCK cells relative to Gly-Sar | ChEMBL. | 16759105 |
max activation (functional) | = 104 % | Activation of human PEPT1 expressed in MDCK cells relative to Gly-Sar | ChEMBL. | 16759105 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.