Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | O-methyltransferase family protein | 0.0677 | 0.0024 | 0.5 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.1639 | 0.1666 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.1599 | 0.1598 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1639 | 0.1666 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1639 | 0.1666 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.1599 | 0.1598 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1599 | 0.1598 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1599 | 0.1598 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1599 | 0.1598 | 1 |
Onchocerca volvulus | 0.0677 | 0.0024 | 0.5 | |
Schistosoma mansoni | calcium-activated potassium channel | 0.1402 | 0.1261 | 0.7532 |
Loa Loa (eye worm) | hypothetical protein | 0.1639 | 0.1666 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.0129 | 0.0776 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1599 | 0.1598 | 0.5 |
Onchocerca volvulus | 0.0677 | 0.0024 | 0.5 | |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1599 | 0.1598 | 0.1784 |
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 0.0024 | 0.0144 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1599 | 0.1598 | 1 |
Brugia malayi | O-methyltransferase family protein | 0.0677 | 0.0024 | 0.5 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.5846 | 0.8845 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1599 | 0.1598 | 0.1578 |
Loa Loa (eye worm) | O-methyltransferase | 0.0677 | 0.0024 | 0.0144 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.1639 | 0.1666 | 0.5 |
Brugia malayi | O-methyltransferase family protein | 0.0677 | 0.0024 | 0.5 |
Brugia malayi | O-methyltransferase | 0.0677 | 0.0024 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = -74 % | Decrease in [35S]-GTP-gammaS, binding to human Cannabinoid receptor 1 expressed in CHO cells at 10 uM; range is -52 to -74% | ChEMBL. | 15801840 |
Decrease (functional) | = -74 % | Decrease in [35S]-GTP-gammaS, binding to human Cannabinoid receptor 1 expressed in CHO cells at 10 uM; range is -52 to -74% | ChEMBL. | 15801840 |
Ki (binding) | = 3467 nM | Inhibition of [3H]-SR-141,716A binding to human CB1 receptor expressed in CHO cells | ChEMBL. | 15801840 |
Ki (binding) | = 3467 nM | Inhibition of [3H]-SR-141,716A binding to human CB1 receptor expressed in CHO cells | ChEMBL. | 15801840 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.