Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | epidermal growth factor receptor | 0.0144 | 0.014 | 0.1241 |
Onchocerca volvulus | 0.0736 | 0.0979 | 1 | |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0078 | 0.0045 | 0.0397 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0144 | 0.014 | 0.1241 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 0.5 |
Brugia malayi | O-methyltransferase family protein | 0.0736 | 0.0979 | 0.8712 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0838 | 0.1124 | 0.5 |
Mycobacterium ulcerans | methyltransferase | 0.0736 | 0.0979 | 0.0734 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0736 | 0.0979 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0078 | 0.0045 | 0.0397 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0043 | 0.0387 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 0.0979 | 0.8712 |
Loa Loa (eye worm) | O-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Schistosoma mansoni | o-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.0045 | 0.0397 |
Brugia malayi | thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0043 | 0.0387 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0838 | 0.1124 | 0.0883 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0838 | 0.1124 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Schistosoma mansoni | o-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.0045 | 0.0397 |
Schistosoma mansoni | o-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0144 | 0.014 | 0.1241 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.0736 | 0.0979 | 0.8316 |
Echinococcus multilocularis | thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Brugia malayi | dihydrofolate reductase family protein | 0.0838 | 0.1124 | 1 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0091 | 0.0813 |
Mycobacterium tuberculosis | Probable methyltransferase | 0.0736 | 0.0979 | 0.1002 |
Echinococcus granulosus | thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0091 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0838 | 0.1124 | 0.1165 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0078 | 0.0045 | 0.0397 |
Brugia malayi | O-methyltransferase family protein | 0.0736 | 0.0979 | 0.8712 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.6354 | 0.8955 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0611 | 0.0802 | 0.5 |
Schistosoma mansoni | o-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0144 | 0.014 | 0.1241 |
Brugia malayi | O-methyltransferase family protein | 0.0736 | 0.0979 | 0.8712 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0144 | 0.014 | 0.1241 |
Onchocerca volvulus | 0.0736 | 0.0979 | 1 | |
Brugia malayi | O-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0043 | 0.0387 |
Loa Loa (eye worm) | thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0232 | 0.0264 | 0.0195 |
Brugia malayi | Dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 34.3 uM | Growth inhibition against HL-60 cell line | ChEMBL. | 15863302 |
GI50 (functional) | = 34.3 uM | Growth inhibition against HL-60 cell line | ChEMBL. | 15863302 |
TGI50 (functional) | 0 uM | Total growth inhibition against HL-60 cell line;NA=not active | ChEMBL. | 15863302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.