TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 460.525 | Formula: C24H16N2O4S2
H donors: 2 H acceptors: 6 LogP: 3.77 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)Cc1csc(c1)c1nc2cc3ccccc3cc2nc1c1scc(c1)CC(=O)O
InChi: 1S/C24H16N2O4S2/c27-21(28)7-13-5-19(31-11-13)23-24(20-6-14(12-32-20)8-22(29)30)26-18-10-16-4-2-1-3-15(16)9-17(18)25-23/h1-6,9-12H,7-8H2,(H,27,28)(H,29,30)
InChiKey: CLRJDJZNLICLJW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ribosomal protein S6 kinase, 70kDa, polypeptide 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0352	0.0105
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	AGC family protein kinase	0.005	0.028	0.6144
Leishmania major	hypothetical protein, conserved	0.0057	0.0391	0.004
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0055	0.0352	0.0074
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0055	0.0352	0.0101
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0485	0.7358	1
Entamoeba histolytica	nitroreductase family protein	0.0057	0.0391	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.0033	0.0006	0.0008
Trypanosoma cruzi	nitroreductase	0.0647	1	1
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0055	0.0352	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Entamoeba histolytica	hypothetical protein	0.0057	0.0391	1
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Mycobacterium ulcerans	hypothetical protein	0.0057	0.0391	1
Mycobacterium leprae	Probable F420 biosynthesis protein FbiB	0.0057	0.0391	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0055	0.0352	0.0346
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0055	0.0352	0.0346
Mycobacterium tuberculosis	Conserved protein	0.0057	0.0391	1
Giardia lamblia	Nitroreductase Fd-NR2	0.0057	0.0391	1
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0055	0.0352	0.0346
Mycobacterium leprae	Possible oxidoreductase	0.0057	0.0391	1
Entamoeba histolytica	nitroreductase family protein	0.0057	0.0391	1
Plasmodium falciparum	GAF domain-related protein, putative	0.0039	0.0104	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trypanosoma brucei	Nitroreductase family, putative	0.0057	0.0391	0.0114
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Entamoeba histolytica	protein kinase, putative	0.005	0.028	0.7127
Echinococcus granulosus	serine/threonine protein kinase	0.0033	0.0006	0.0008
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Mycobacterium ulcerans	oxidoreductase	0.0057	0.0391	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Trichomonas vaginalis	AGC family protein kinase	0.005	0.028	0.6144
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Mycobacterium tuberculosis	Probable F420 biosynthesis protein FbiB	0.0057	0.0391	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0033	0.0006	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Toxoplasma gondii	AGC kinase	0.005	0.028	1
Trichomonas vaginalis	AGC family protein kinase	0.005	0.028	0.6144
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Mycobacterium ulcerans	F420-0--gamma-glutamyl ligase	0.0057	0.0391	1
Entamoeba histolytica	nitroreductase family protein	0.0057	0.0391	1
Trichomonas vaginalis	AGC family protein kinase	0.005	0.028	0.6144
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Mycobacterium ulcerans	nitroreductase	0.0057	0.0391	1
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0033	0.0006	0.0008
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0485	0.7358	1
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0055	0.0352	0.0478
Loa Loa (eye worm)	hypothetical protein	0.043	0.6469	0.9061
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Trypanosoma cruzi	nitroreductase	0.0647	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0391	0.0162
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0352	0.8637
Trypanosoma brucei	Nitroreductase family, putative	0.0057	0.0391	0.0114
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0104	1
Trypanosoma brucei	nitroreductase	0.0647	1	1
Mycobacterium ulcerans	nitroreductase	0.0057	0.0391	1
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0485	0.7358	1
Giardia lamblia	Nitroreductase family protein fused to ferredoxin domain Fd-NR1	0.0057	0.0391	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Mycobacterium tuberculosis	Possible oxidoreductase	0.0057	0.0391	1
Trichomonas vaginalis	AGC family protein kinase	0.005	0.028	0.6144
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0055	0.0352	0.0478
Brugia malayi	nitroreductase family protein	0.0057	0.0391	0.0156
Mycobacterium ulcerans	nitroreductase	0.0057	0.0391	1
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0055	0.0352	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.005	0.028	0.6144
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Mycobacterium ulcerans	hypothetical protein	0.0057	0.0391	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Giardia lamblia	Nitroreductase family protein	0.0057	0.0391	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Mycobacterium tuberculosis	Putative oxidoreductase	0.0057	0.0391	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0033	0.0006	0.0008
Onchocerca volvulus	Iodotyrosine dehalogenase 1 homolog	0.0057	0.0391	0.5
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0055	0.0352	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0055	0.0352	0.8637
Mycobacterium tuberculosis	Conserved protein Acg	0.0057	0.0391	1
Entamoeba histolytica	protein kinase, putative	0.005	0.028	0.7127
Mycobacterium ulcerans	nitroreductase	0.0057	0.0391	1
Loa Loa (eye worm)	hypothetical protein	0.047	0.7111	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0055	0.0352	0.8637
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0391	1
Trichomonas vaginalis	AGC family protein kinase	0.005	0.028	0.6144
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0055	0.0352	0.8637
Entamoeba histolytica	protein kinase, putative	0.005	0.028	0.7127

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.64 uM	In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
IC50 (binding)	= 0.64 uM	In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= -23 %	In vitro percent inhibition of c-Jun N-terminal kinase 1-alpha 1 at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= -23 %	In vitro percent inhibition of c-Jun N-terminal kinase 1-alpha 1 at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= -14 %	In vitro percent inhibition of Insulin receptor at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= -14 %	In vitro percent inhibition of Insulin receptor at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= -7 %	In vitro percent inhibition of v-Abl tyrosine kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= -7 %	In vitro percent inhibition of v-Abl tyrosine kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= -5 %	In vitro percent inhibition of Cyclin-dependent kinase 2-cyclin A at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 8 %	In vitro percent inhibition of p56 Lck tyrosine kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 8 %	In vitro percent inhibition of p56 Lck tyrosine kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 10 %	In vitro percent inhibition of Ribosomal protein S6 kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 10 %	In vitro percent inhibition of Ribosomal protein S6 kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 17 %	In vitro percent inhibition of v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 17 %	In vitro percent inhibition of Protein kinase B, alpha at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 17 %	In vitro percent inhibition of v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 17 %	In vitro percent inhibition of Protein kinase B, alpha at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 18 %	In vitro percent inhibition of Protein kinase ROCK2 at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 18 %	In vitro percent inhibition of Casein kinase 1 alpha at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 18 %	In vitro percent inhibition of Protein kinase ROCK2 at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 18 %	In vitro percent inhibition of Casein kinase 1 alpha at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 21 %	In vitro percent inhibition of Met proto-oncogene tyrosine kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 21 %	In vitro percent inhibition of Met proto-oncogene tyrosine kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 22 %	In vitro percent inhibition of Platelet-derived growth factor receptor, beta polypeptide at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 22 %	In vitro percent inhibition of Glycogen synthase kinase 3 beta at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 22 %	In vitro percent inhibition of Platelet-derived growth factor receptor, beta polypeptide at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 22 %	In vitro percent inhibition of Glycogen synthase kinase 3 beta at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 27 %	In vitro percent inhibition of Ribosomal S6 kinase 1 at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 29 %	In vitro percent inhibition of c-Src tyrosine kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 29 %	In vitro percent inhibition of c-Src tyrosine kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 37 %	In vitro percent inhibition of I-kappa-B-kinase beta at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 37 %	In vitro percent inhibition of I-kappa-B-kinase beta at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 40 %	In vitro percent inhibition of RAF proto-oncogene serine/threonine-protein kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 40 %	In vitro percent inhibition of RAF proto-oncogene serine/threonine-protein kinase at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 54 %	In vitro percent inhibition of Mitogen-activated protein kinase 3 at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 54 %	In vitro percent inhibition of Epidermal growth factor receptor at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 54 %	In vitro percent inhibition of Mitogen-activated protein kinase 3 at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
Inhibition (binding)	= 54 %	In vitro percent inhibition of Epidermal growth factor receptor at 10 uM concentration of compound dissolved in 100% DMSO using 5''-[gamma-33P]-triphosphate	ChEMBL.	15925511
logP (ADMET)	= 4.11	Partition coefficient (logP)	ChEMBL.	15925511

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL192909

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 334595