Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Starlite/ChEMBL | References |
Escherichia coli | UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding | Starlite/ChEMBL | References |
Staphylococcus aureus | UDP-N-acetylmuramate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0774 | 0.5202 | 0.5202 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0774 | 0.5202 | 0.5202 |
Treponema pallidum | UDP-N-acetylenolpyruvoylglucosamine reductase | 0.1286 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylenolpyruvoylglucosamine reductase | 0.1286 | 1 | 1 |
Mycobacterium ulcerans | UDP-N-acetylenolpyruvoylglucosamine reductase | 0.1286 | 1 | 1 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.0556 | 0.316 | 0.316 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0218 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase) | 0.1286 | 1 | 1 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE) | 0.1286 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.2 uM | Inhibitory concentration against MurB enzyme in Staphylococcus aureus | ChEMBL. | 15863310 |
IC50 (binding) | = 5.2 uM | Inhibitory concentration against MurB enzyme in Staphylococcus aureus | ChEMBL. | 15863310 |
IC50 (binding) | = 5.8 uM | Inhibitory concentration against MurB enzyme in Escherichia coli | ChEMBL. | 15863310 |
IC50 (binding) | = 5.8 uM | Inhibitory concentration against MurB enzyme in Escherichia coli | ChEMBL. | 15863310 |
IC50 (binding) | = 9.6 uM | Inhibitory concentration against MurA enzyme in Escherichia coli | ChEMBL. | 15863310 |
IC50 (binding) | = 9.6 uM | Inhibitory concentration against MurA enzyme in Escherichia coli | ChEMBL. | 15863310 |
MIC (functional) | = 3.12 uM | Minimum inhibitory concentration against cell wall biosynthesis of penicillin resistant Streptococcus pneumoniae GC 1894 (PRSP) | ChEMBL. | 15863310 |
MIC (functional) | = 12.5 uM | Minimum inhibitory concentration against cell wall biosynthesis of methicillin resistant Staphylococcus aureus GC 1131 | ChEMBL. | 15863310 |
MIC (functional) | = 12.5 uM | Minimum inhibitory concentration against cell wall biosynthesis of methicillin susceptible Staphylococcus aureus GC 4543 | ChEMBL. | 15863310 |
MIC (functional) | = 12.5 uM | Minimum inhibitory concentration against cell wall biosynthesis of vancomycin susceptible (ATCC) Enterococcus faecalis GC 4555 | ChEMBL. | 15863310 |
MIC (functional) | = 12.5 uM | Minimum inhibitory concentration against cell wall biosynthesis of vancomycin resistant Enterococcus faecalis GC 2242 (VRE) | ChEMBL. | 15863310 |
MIC (functional) | = 25 uM | Minimum inhibitory concentration against cell wall biosynthesis of methicillin-susceptible Coagulase negative staphylococcus GC 646 (MSCNS) | ChEMBL. | 15863310 |
MIC (functional) | = 100 uM | Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4560 | ChEMBL. | 15863310 |
MIC (functional) | = 100 uM | Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4560 | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of penicillin resistant Streptococcus pneumoniae GC 1894 (PRSP) in the presence of 4% bovine serum albumin | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4559 | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4559 | ChEMBL. | 15863310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.