Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0214 | 1 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0214 | 1 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0214 | 1 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0214 | 1 | 0.5 |
Onchocerca volvulus | 0.0214 | 1 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0214 | 1 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0214 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0214 | 1 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0214 | 1 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0214 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 nM | Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) as substrate, 50 mM Tris/HCl buffer, pH 7.8, incubated for 1 h at 37 degrees C | ChEMBL. | 16107158 |
IC50 (binding) | = 14 nM | Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) as substrate, 50 mM Tris/HCl buffer, pH 7.8, incubated for 1 h at 37 degrees C | ChEMBL. | 16107158 |
IC50 (binding) | = 1100 nM | Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) as substrate, 50 mM Tris/HCl buffer, pH 7.8, incubated for 1 h at 37 degrees C | ChEMBL. | 16107158 |
IC50 (binding) | = 1100 nM | Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) as substrate, 50 mM Tris/HCl buffer, pH 7.8, incubated for 1 h at 37 degrees C | ChEMBL. | 16107158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.