Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1415 | 0.1261 | 0.5 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.141 | 0.1254 | 0.3738 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1415 | 0.1261 | 0.1209 |
Schistosoma mansoni | protein kinase | 0.141 | 0.1254 | 0.1202 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0613 | 0.0103 | 0.0138 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1415 | 0.1261 | 0.5 |
Loa Loa (eye worm) | subtilase | 0.747 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1415 | 0.1261 | 0.3759 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.2797 | 0.3255 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0583 | 0.0059 | 0.0059 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.747 | 1 | 1 |
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.2797 | 0.3255 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0664 | 0.0176 | 0.5 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0544 | 0.0003 | 0.0003 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0664 | 0.0176 | 1 |
Echinococcus multilocularis | activin receptor type | 0.0637 | 0.0138 | 0.0246 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0664 | 0.0176 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0544 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.1415 | 0.1261 | 0.1261 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0664 | 0.0176 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.1415 | 0.1261 | 0.1261 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.1408 | 0.1251 | 0.1251 |
Schistosoma mansoni | protein kinase | 0.0635 | 0.0135 | 0.0076 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1415 | 0.1261 | 0.3759 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.141 | 0.1254 | 0.3738 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.1408 | 0.1251 | 0.1251 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0613 | 0.0103 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0583 | 0.0059 | 0.0059 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1415 | 0.1261 | 0.5 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0544 | 0.0003 | 0.0003 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.141 | 0.1254 | 0.3738 |
Brugia malayi | CHE-14 protein | 0.0583 | 0.0059 | 0.0059 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.0637 | 0.0138 | 0.0246 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1415 | 0.1261 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1415 | 0.1261 | 0.5 |
Echinococcus granulosus | activin receptor type | 0.0637 | 0.0138 | 0.0246 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 54.92 uM | In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells) | ChEMBL. | 15857119 |
LD50 (functional) | = 10.4 uM | Lethal dose required to inhibit the growth of human KB (nasopharyngeal carcinoma) cell line | ChEMBL. | 15857119 |
TI (functional) | = 0.19 | Therapeutic index (TI) value as ratio of lethal dose (LD50) to the inhibitory concentration (IC50) | ChEMBL. | 15857119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.