Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.3343 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.3343 | 1 | 1 |
Onchocerca volvulus | Legumain homolog | 0.3343 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.3343 | 1 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0027 | 0.0008 | 0.0036 |
Schistosoma mansoni | glycosylphosphatidylinositol:protein transamidase (C13 family) | 0.0776 | 0.2265 | 0.2265 |
Entamoeba histolytica | GPI-anchor transamidase, putative | 0.0776 | 0.2265 | 1 |
Schistosoma mansoni | hypothetical protein | 0.2567 | 0.7663 | 0.7663 |
Brugia malayi | RNase H family protein | 0.0027 | 0.0008 | 0.0008 |
Giardia lamblia | GPI-anchor transamidase, putative | 0.0776 | 0.2265 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.3343 | 1 | 1 |
Giardia lamblia | Ribonuclease H | 0.0027 | 0.0008 | 0.0036 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0776 | 0.2265 | 0.2265 |
Trypanosoma brucei | ribonuclease H1 | 0.0027 | 0.0008 | 0.0036 |
Toxoplasma gondii | peptidase c13 family protein | 0.0776 | 0.2265 | 1 |
Toxoplasma gondii | ribonuclease HI protein | 0.0027 | 0.0008 | 0.0036 |
Loa Loa (eye worm) | peptidase C13 family protein | 0.3343 | 1 | 1 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.3343 | 1 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0027 | 0.0008 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0029 | 0.0015 | 0.0066 |
Schistosoma mansoni | phosphoglucomutase | 0.0027 | 0.0008 | 0.0008 |
Plasmodium falciparum | GPI-anchor transamidase, putative | 0.0776 | 0.2265 | 1 |
Echinococcus multilocularis | GPI anchor transamidase | 0.0776 | 0.2265 | 1 |
Leishmania major | GPI-anchor transamidase subunit 8 (GPI8), putative | 0.0776 | 0.2265 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0027 | 0.0008 | 0.0008 |
Echinococcus multilocularis | ribonuclease H1 | 0.0027 | 0.0008 | 0.0036 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.3343 | 1 | 1 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0027 | 0.0008 | 0.0008 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0015 | 0.0066 |
Brugia malayi | GPI-anchor transamidase | 0.0776 | 0.2265 | 0.2265 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0229 | 0.0229 |
Leishmania major | ribonuclease H1, putative | 0.0027 | 0.0008 | 0.0036 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.3343 | 1 | 1 |
Brugia malayi | RNase H family protein | 0.0027 | 0.0008 | 0.0008 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0229 | 0.1011 |
Schistosoma mansoni | phosphoglucomutase | 0.0027 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0776 | 0.2265 | 0.2265 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0776 | 0.2265 | 0.2265 |
Schistosoma mansoni | family C13 non-peptidase homologue (C13 family) | 0.3343 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CD, family C13, putative | 0.0776 | 0.2265 | 1 |
Echinococcus granulosus | ribonuclease H1 | 0.0027 | 0.0008 | 0.0036 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0027 | 0.0008 | 0.0036 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0776 | 0.2265 | 0.2265 |
Trypanosoma brucei | GPI-anchor transamidase subunit 8 (GPI8) | 0.0776 | 0.2265 | 1 |
Plasmodium vivax | GPI-anchor transamidase, putative | 0.0776 | 0.2265 | 1 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.3343 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0015 | 0.0066 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0027 | 0.0008 | 0.5 |
Echinococcus granulosus | GPI anchor transamidase | 0.0776 | 0.2265 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0015 | 0.0066 |
Brugia malayi | RNase H family protein | 0.0027 | 0.0008 | 0.0008 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.3343 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0.0015 | 0.0066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.071 uM | Inhibitory constant against HIV-1 reverse transcriptase | ChEMBL. | 15801860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.