Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Hyaluronidase | 0.0654 | 0.4759 | 0.4536 |
Brugia malayi | G-protein coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0105 | 0.0407 | 0.0856 |
Echinococcus multilocularis | geminin | 0.0181 | 0.101 | 0.1001 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0105 | 0.0407 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | RE15519p | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | AKH receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.101 | 0.0628 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0865 | 0.6424 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0105 | 0.0407 | 0.5 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Melatonin receptor type 1A | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | larval opioid receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | neuropeptide F receptor | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | G protein-coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Dopamine receptor protein 1 | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | neuropeptide F receptor | 0.0105 | 0.0407 | 0.0856 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.101 | 0.0628 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0654 | 0.4759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hyaluronidase | 0.0654 | 0.4759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.178 | 0.374 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.1356 | 0.5 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Serotonin receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | G-protein coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0654 | 0.4759 | 0.4536 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | ORL1-like opioid receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | sulfakinin receptor protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Dopamine receptor protein 2 | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0654 | 0.4759 | 0.7233 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | Dopamine receptor | 0.0105 | 0.0407 | 0.0856 |
Echinococcus granulosus | geminin | 0.0181 | 0.101 | 0.1384 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | GnHR receptor homolog | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Hyaluronidase family protein | 0.0654 | 0.4759 | 1 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | putative neuropeptide receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | follicle stimulating hormone receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0105 | 0.0407 | 0.0856 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -29 % | Percentage change in volume of pleural fluid in the 5-h Evans Blue-Carrageenan pleural assay for the compound at dose 100 mg/kg | ChEMBL. | 6481768 |
Change (functional) | = -25 % | Percentage change in volume of pleural fluid in the 5-h Evans Blue-Carrageenan pleural assay for Indomethacin 4.0 mg/kg | ChEMBL. | 6481768 |
Change (functional) | = -3 % | Percentage change in volume of pleural fluid in the 5-h Evans Blue-Carrageenan pleural assay for the compound at dose 4 mg/kg | ChEMBL. | 6481768 |
Efficacy ratio (functional) | = 1.43 | Oral antiinflammatory activity, measured in rats at the dose of 316 mg/kg | ChEMBL. | 6481768 |
Efficacy ratio (functional) | = 1.46 | Oral antiinflammatory activity, measured in rats at the dose of 316 mg/kg | ChEMBL. | 6481768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.