Detailed information for compound 336471

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.369 | Formula: C20H28Cl2N4O
  • H donors: 1 H acceptors: 2 LogP: 5.19 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCC(Nc1ccnc(n1)COc1ccc(cc1Cl)Cl)C)CC
  • InChi: 1S/C20H28Cl2N4O/c1-4-26(5-2)12-6-7-15(3)24-19-10-11-23-20(25-19)14-27-18-9-8-16(21)13-17(18)22/h8-11,13,15H,4-7,12,14H2,1-3H3,(H,23,24,25)
  • InChiKey: FVAIFFNIFRJCNH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cation transporter family protein 0.032 0.0284 0.0391
Loa Loa (eye worm) histone deacetylase 7A 0.0038 0.0014 0.0313
Loa Loa (eye worm) hypothetical protein 0.0141 0.0112 0.2591
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0262 0.0228 0.0313
Echinococcus granulosus protection of telomeres protein 1 0.0554 0.0507 1
Entamoeba histolytica hypothetical protein 0.0141 0.0112 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0262 0.0228 0.5267
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0262 0.0228 0.8014
Loa Loa (eye worm) hypothetical protein 0.032 0.0284 0.6573
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0051 0.0027 0.0924
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0121 0.0093 0.0127
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0121 0.0093 0.2142
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0121 0.0093 0.1824
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0262 0.0228 0.4485
Trichomonas vaginalis histone deacetylase, putative 0.0069 0.0044 1
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0121 0.0093 0.0127
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0121 0.0093 0.1824
Schistosoma mansoni neurotransmitter gated ion channel 0.0121 0.0093 0.3258
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0141 0.0112 0.0154
Echinococcus multilocularis histone deacetylase 1 0.0069 0.0044 0.0853
Echinococcus multilocularis histone deacetylase 3 0.0069 0.0044 0.0853
Echinococcus granulosus histone deacetylase 3 0.0069 0.0044 0.0853
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0087 0.0061 0.1186
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0475 0.0432 0.8515
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Trypanosoma cruzi histone deacetylase, putative 0.0038 0.0014 0.005
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Loa Loa (eye worm) hypothetical protein 0.0141 0.0112 0.2591
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0262 0.0228 0.4485
Loa Loa (eye worm) hypothetical protein 0.02 0.0169 0.3897
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0262 0.0228 0.4485
Loa Loa (eye worm) hypothetical protein 0.0141 0.0112 0.2591
Loa Loa (eye worm) histone deacetylase 3 0.0069 0.0044 0.1002
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Schistosoma mansoni nAChR subunit 0.0262 0.0228 0.8014
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0262 0.0228 0.8014
Loa Loa (eye worm) raf kinase 0.0027 0.0003 0.0058
Plasmodium falciparum histone deacetylase 1 0.0069 0.0044 0.0162
Schistosoma mansoni histone deacetylase 0.0069 0.0044 0.1524
Giardia lamblia Histone deacetylase 0.0069 0.0044 0.0162
Echinococcus granulosus raf serine:threonine protein kinase 0.0027 0.0003 0.0049
Schistosoma mansoni nAChR subunit 0.0262 0.0228 0.8014
Brugia malayi Raf kinase 0.0027 0.0003 0.0003
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2861 0.2715 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0121 0.0093 0.0127
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0262 0.0228 0.0313
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0475 0.0432 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0069 0.0044 0.0159
Echinococcus granulosus glycine receptor subunit beta 0.0262 0.0228 0.4485
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0051 0.0027 0.0036
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0141 0.0112 0.0154
Schistosoma mansoni neurotransmitter gated ion channel 0.0121 0.0093 0.3258
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0003 0.0088
Brugia malayi histone deacetylase 3 (HD3) 0.0069 0.0044 0.006
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0069 0.0044 1
Onchocerca volvulus 0.0262 0.0228 0.0227
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0262 0.0228 0.4485
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Loa Loa (eye worm) ACC-1 protein 0.0262 0.0228 0.5267
Loa Loa (eye worm) hypothetical protein 0.0109 0.0082 0.1889
Schistosoma mansoni histone deacetylase 4 5 0.0038 0.0014 0.0477
Trichomonas vaginalis histone deacetylase, putative 0.0069 0.0044 1
Onchocerca volvulus 0.032 0.0284 0.0284
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0141 0.0112 0.3942
Echinococcus multilocularis histone deacetylase 6 0.0038 0.0014 0.0267
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0262 0.0228 0.8014
Echinococcus granulosus histone deacetylase 6 0.0038 0.0014 0.0267
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0121 0.0093 0.1824
Trichomonas vaginalis histone deacetylase, putative 0.0069 0.0044 1
Echinococcus multilocularis nAChR subunit 0.0262 0.0228 0.4485
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0121 0.0093 0.0127
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Onchocerca volvulus 0.0262 0.0228 0.0227
Leishmania major histone deacetylase, putative 0.0069 0.0044 0.011
Loa Loa (eye worm) histone deacetylase 1 0.0069 0.0044 0.1002
Echinococcus granulosus nAChR subunit 0.0262 0.0228 0.4485
Onchocerca volvulus 0.0121 0.0093 0.0092
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0262 0.0228 0.0313
Onchocerca volvulus 0.0141 0.0112 0.0112
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0141 0.0112 0.0154
Echinococcus multilocularis glycine receptor subunit beta 0.0262 0.0228 0.4485
Echinococcus granulosus histone acetyltransferase KAT2B 0.0026 0.0002 0.0027
Schistosoma mansoni nAChR subunit 0.0121 0.0093 0.3258
Brugia malayi hypothetical protein 0.0121 0.0093 0.0127
Schistosoma mansoni acetylcholine receptor subunit beta 0.0121 0.0093 0.3258
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0475 0.0432 0.0594
Echinococcus granulosus L aminoadipate semialdehyde 0.0051 0.0027 0.0517
Loa Loa (eye worm) hypothetical protein 0.0141 0.0112 0.2591
Brugia malayi histone deacetylase 1 (HD1) 0.0069 0.0044 0.006
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Trypanosoma cruzi histone deacetylase, putative 0.0038 0.0014 0.005
Schistosoma mansoni histone deacetylase 0.0069 0.0044 0.1524
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.032 0.0284 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0026 0.0002 0.0005
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0121 0.0093 0.2142
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2861 0.2715 1
Toxoplasma gondii RNA-directed DNA polymerase 0.2861 0.2715 1
Brugia malayi Histone deacetylase 1 0.0069 0.0044 0.006
Loa Loa (eye worm) hypothetical protein 0.0141 0.0112 0.2591
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0262 0.0228 0.8014
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0262 0.0228 0.5267
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0262 0.0228 0.0313
Onchocerca volvulus 0.032 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0475 0.0432 0.8515
Onchocerca volvulus 0.0141 0.0112 0.0112
Echinococcus multilocularis raf serine:threonine protein kinase 0.0027 0.0003 0.0049
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0121 0.0093 0.1824
Echinococcus multilocularis nAChR subunit 0.0141 0.0112 0.2206
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0475 0.0432 0.8515
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Leishmania major histone deacetylase, putative 0.0069 0.0044 0.011
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0262 0.0228 0.4485
Schistosoma mansoni nAChR subunit 0.0262 0.0228 0.8014
Plasmodium falciparum telomerase reverse transcriptase 0.2861 0.2715 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0262 0.0228 0.4485
Brugia malayi hypothetical protein 0.0121 0.0093 0.0127
Schistosoma mansoni histone deacetylase hda2 0.0038 0.0014 0.0477
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0262 0.0228 0.0313
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0262 0.0228 0.5267
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0262 0.0228 0.0313
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0262 0.0228 0.0313
Trypanosoma cruzi histone deacetylase 1, putative 0.0069 0.0044 0.0159
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0262 0.0228 0.5267
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0026 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0109 0.0082 0.2874
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0475 0.0432 0.8515
Brugia malayi excitatory GABA receptor EXP-1A 0.0262 0.0228 0.0313
Brugia malayi hypothetical protein 0.0121 0.0093 0.0127
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0475 0.0432 0.8515
Trypanosoma brucei histone deacetylase 1 0.0069 0.0044 0.0159
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0262 0.0228 0.0313
Brugia malayi hypothetical protein 0.0109 0.0082 0.0112
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0141 0.0112 0.0154
Echinococcus granulosus glycine receptor subunit alpha 1 0.0262 0.0228 0.4485
Loa Loa (eye worm) histone deacetylase 0.0038 0.0014 0.0313
Trypanosoma brucei histone deacetylase 3 0.0038 0.0014 0.005
Echinococcus granulosus histone deacetylase 7 0.0038 0.0014 0.0267
Loa Loa (eye worm) acetylcholine receptor protein 0.0121 0.0093 0.2142
Loa Loa (eye worm) hypothetical protein 0.0141 0.0112 0.2591
Trichomonas vaginalis histone deacetylase, putative 0.0069 0.0044 1
Onchocerca volvulus 0.0262 0.0228 0.0227
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0026 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Echinococcus granulosus histone deacetylase 6 0.0038 0.0014 0.0267
Brugia malayi Histone deacetylase family protein 0.0038 0.0014 0.0019
Plasmodium vivax histone deacetylase 1, putative 0.0069 0.0044 0.0159
Onchocerca volvulus Putative nachr subunit 0.0475 0.0432 0.0432
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0069 0.0044 1
Plasmodium falciparum histone deacetylase 2 0.0038 0.0014 0.0052
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0262 0.0228 0.4485
Brugia malayi hypothetical protein 0.0121 0.0093 0.0127
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0262 0.0228 0.4485
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Onchocerca volvulus 0.032 0.0284 0.0284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0262 0.0228 0.0313
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0069 0.0044 1
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0262 0.0228 0.4485
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0262 0.0228 0.0313
Plasmodium vivax telomerase reverse transcriptase, putative 0.2861 0.2715 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0112 0.2591
Plasmodium vivax histone deacetylase, putative 0.0038 0.0014 0.005
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.032 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Toxoplasma gondii histone deacetylase HDAC1 0.0038 0.0014 0.005
Echinococcus granulosus glycine receptor subunit beta 0.0262 0.0228 0.4485
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Loa Loa (eye worm) LGC-31 protein 0.0262 0.0228 0.5267
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Trypanosoma brucei histone deacetylase, putative 0.0038 0.0014 0.005
Brugia malayi hypothetical protein 0.0109 0.0082 0.0112
Leishmania major telomerase reverse transcriptase, putative 0.2861 0.2715 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Trypanosoma brucei telomerase reverse transcriptase 0.2861 0.2715 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0262 0.0228 0.0313
Schistosoma mansoni acetylcholine receptor-related 0.0121 0.0093 0.3258
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Echinococcus granulosus histone deacetylase 0.0038 0.0014 0.0267
Toxoplasma gondii histone deacetylase HDAC3 0.0069 0.0044 0.0159
Plasmodium falciparum histone deacetylase, putative 0.0038 0.0014 0.0052
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0121 0.0093 0.0127
Echinococcus multilocularis protection of telomeres protein 1 0.0554 0.0507 1
Loa Loa (eye worm) acetyltransferase 0.0087 0.0061 0.1392
Trypanosoma cruzi histone deacetylase, putative 0.0038 0.0014 0.005
Trypanosoma brucei histone deacetylase 4 0.0038 0.0014 0.005
Echinococcus multilocularis histone deacetylase 6 0.0038 0.0014 0.0267
Brugia malayi hypothetical protein 0.0121 0.0093 0.0127
Schistosoma mansoni nAChR subunit 0.0121 0.0093 0.3258
Echinococcus multilocularis glycine receptor subunit beta 0.0262 0.0228 0.4485
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0475 0.0432 0.8515
Schistosoma mansoni nAChR subunit 0.0262 0.0228 0.8014
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0262 0.0228 0.4485
Loa Loa (eye worm) ACC-1 protein 0.0262 0.0228 0.5267
Loa Loa (eye worm) GABA receptor subunit 0.0141 0.0112 0.2591
Schistosoma mansoni nAChR subunit 0.0262 0.0228 0.8014
Trichomonas vaginalis histone deacetylase, putative 0.0069 0.0044 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0112 0.2591
Onchocerca volvulus 0.0121 0.0093 0.0092
Echinococcus granulosus histone acetyltransferase KAT2B 0.0084 0.0058 0.114
Loa Loa (eye worm) hypothetical protein 0.0051 0.0027 0.0607
Brugia malayi acetyltransferase, GNAT family protein 0.0087 0.0061 0.0083
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Echinococcus multilocularis L aminoadipate semialdehyde 0.0051 0.0027 0.0517
Echinococcus multilocularis histone deacetylase 7 0.0038 0.0014 0.0267
Echinococcus granulosus glycine receptor subunit alpha 1 0.0262 0.0228 0.4485
Schistosoma mansoni histone deacetylase 4 5 0.0038 0.0014 0.0477
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0262 0.0228 0.4485
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0262 0.0228 0.4485
Plasmodium vivax histone deacetylase 2, putative 0.0038 0.0014 0.005
Onchocerca volvulus 0.0051 0.0027 0.0026
Echinococcus granulosus nAChR subunit 0.0141 0.0112 0.2206
Schistosoma mansoni neurotransmitter gated ion channel 0.0141 0.0112 0.3942
Brugia malayi Cation transporter family protein 0.0262 0.0228 0.0313
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Loa Loa (eye worm) hypothetical protein 0.0069 0.0044 0.1002
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Schistosoma mansoni nAChR subunit 0.0262 0.0228 0.8014
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0262 0.0228 0.0313
Loa Loa (eye worm) hypothetical protein 0.0262 0.0228 0.5267
Toxoplasma gondii histone deacetylase HDAC2 0.0069 0.0044 0.0159
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0262 0.0228 0.4485
Schistosoma mansoni nAChR subunit 0.0262 0.0228 0.8014
Entamoeba histolytica histone deacetylase, putative 0.0069 0.0044 0.3903
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0262 0.0228 0.0313
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0141 0.0112 0.3942
Echinococcus granulosus histone deacetylase 1 0.0069 0.0044 0.0853
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Loa Loa (eye worm) hypothetical protein 0.0475 0.0432 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0262 0.0228 0.5267
Brugia malayi Cation transporter family protein 0.0262 0.0228 0.0313
Brugia malayi Histone deacetylase family protein 0.0038 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.032 0.0284 0.6573
Trichomonas vaginalis histone deacetylase, putative 0.0069 0.0044 1
Echinococcus granulosus histone deacetylase 6 0.0038 0.0014 0.0267
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0087 0.0061 0.2118
Loa Loa (eye worm) hypothetical protein 0.0109 0.0082 0.1889
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0262 0.0228 0.0313
Brugia malayi Telomerase reverse transcriptase 0.7613 0.7262 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0262 0.0228 0.0313
Echinococcus multilocularis histone deacetylase 0.0038 0.0014 0.0267
Giardia lamblia Telomerase catalytic subunit 0.2861 0.2715 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0121 0.0093 0.1824
Onchocerca volvulus 0.0121 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0121 0.0093 0.0127
Loa Loa (eye worm) hypothetical protein 0.0121 0.0093 0.2142
Echinococcus multilocularis histone deacetylase 6 0.0038 0.0014 0.0267

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.2 uM Inhibitory concentration against human C-C chemokine receptor type 4 ChEMBL. 15863339

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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