Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Telomerase catalytic subunit | 0.267 | 0.2657 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0009 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0009 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.267 | 0.2657 | 0.5 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.0547 | 0.0463 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.267 | 0.2657 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.267 | 0.2657 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.267 | 0.2657 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.0009 | 0.1965 |
Brugia malayi | Telomerase reverse transcriptase | 0.7104 | 0.724 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0044 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.267 | 0.2657 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.267 | 0.2657 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.267 | 0.2657 | 0.5 |
Echinococcus granulosus | protection of telomeres protein 1 | 0.0547 | 0.0463 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | mg kg-1 | Inhibition of 5-lipoxygenase-mediated platelet activating factor induced thrombosis in male mice | ChEMBL. | 15863327 |
ED50 (functional) | ND 0 mg kg-1 | Inhibition of 5-lipoxygenase-mediated platelet activating factor induced thrombosis in male mice | ChEMBL. | 15863327 |
IC50 (functional) | > 1 uM | Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole blood | ChEMBL. | 15863327 |
IC50 (functional) | > 1 uM | Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole blood | ChEMBL. | 15863327 |
Inhibition (functional) | = 1 % | Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole blood at 1 uM concentration | ChEMBL. | 15863327 |
Inhibition (functional) | = 1 % | Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole blood at 1 uM concentration | ChEMBL. | 15863327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.