Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.0045 | 0.0397 |
Brugia malayi | thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0043 | 0.0387 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 1 |
Schistosoma mansoni | o-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 0.0979 | 0.8712 |
Loa Loa (eye worm) | O-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0043 | 0.0387 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0078 | 0.0045 | 0.0397 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0736 | 0.0979 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0838 | 0.1124 | 0.5 |
Mycobacterium ulcerans | methyltransferase | 0.0736 | 0.0979 | 0.0734 |
Brugia malayi | O-methyltransferase family protein | 0.0736 | 0.0979 | 0.8712 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0144 | 0.014 | 0.1241 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0078 | 0.0045 | 0.0397 |
Onchocerca volvulus | 0.0736 | 0.0979 | 1 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0144 | 0.014 | 0.1241 |
Loa Loa (eye worm) | thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Brugia malayi | O-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0043 | 0.0387 |
Brugia malayi | Dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0232 | 0.0264 | 0.0195 |
Schistosoma mansoni | o-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0144 | 0.014 | 0.1241 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0144 | 0.014 | 0.1241 |
Brugia malayi | O-methyltransferase family protein | 0.0736 | 0.0979 | 0.8712 |
Onchocerca volvulus | 0.0736 | 0.0979 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.6354 | 0.8955 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0611 | 0.0802 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0078 | 0.0045 | 0.0397 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0838 | 0.1124 | 0.1165 |
Brugia malayi | O-methyltransferase family protein | 0.0736 | 0.0979 | 0.8712 |
Echinococcus granulosus | thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Mycobacterium tuberculosis | Probable methyltransferase | 0.0736 | 0.0979 | 0.1002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0091 | 0.5 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0091 | 0.0813 |
Brugia malayi | dihydrofolate reductase family protein | 0.0838 | 0.1124 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0232 | 0.0264 | 0.2351 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.0736 | 0.0979 | 0.8316 |
Schistosoma mansoni | tyrosine kinase | 0.0144 | 0.014 | 0.1241 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0611 | 0.0802 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Schistosoma mansoni | o-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.0045 | 0.0397 |
Schistosoma mansoni | o-methyltransferase | 0.0736 | 0.0979 | 0.8712 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0838 | 0.1124 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0838 | 0.1124 | 0.0883 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0838 | 0.1124 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 17.9 uM | Growth inhibition against HL-60 cell line | ChEMBL. | 15863302 |
GI50 (functional) | = 17.9 uM | Growth inhibition against HL-60 cell line | ChEMBL. | 15863302 |
GI50 (functional) | = 88.4 uM | Total growth inhibition against HL-60 cell line | ChEMBL. | 15863302 |
TGI50 (functional) | = 88.4 uM | Total growth inhibition against HL-60 cell line | ChEMBL. | 15863302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.