Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.000877102 | 0.000847926 | 0.5 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.00535676 | 0.0609465 | 0.0601496 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00383695 | 0.040557 | 0.0397427 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.00383695 | 0.040557 | 0.0397427 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0564185 | 0.745986 | 0.74577 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00535676 | 0.0609465 | 0.0601496 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0753523 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044251 | 0.0484475 | 0.04764 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0189338 | 0.243095 | 0.325103 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Brugia malayi | protein kinase C II. | 0.00151981 | 0.00947038 | 0.00862977 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.00395471 | 0.0421369 | 0.041324 |
Brugia malayi | Protein kinase domain containing protein | 0.0217479 | 0.280849 | 0.280238 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0564185 | 0.745986 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00151981 | 0.00947038 | 0.00862977 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.00151981 | 0.00947038 | 0.00862977 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0753523 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0753523 | 1 | 1 |
Plasmodium vivax | topoisomerase I, putative | 0.0753523 | 1 | 0.5 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0753523 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0564185 | 0.745986 | 0.74577 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0217479 | 0.280849 | 0.280238 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0564185 | 0.745986 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.000877102 | 0.000847926 | 0.5 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.00383695 | 0.040557 | 0.0397427 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0217479 | 0.280849 | 0.280238 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.00146525 | 0.00873843 | 0.0078972 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0753523 | 1 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.00146525 | 0.00873843 | 0.0078972 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00535676 | 0.0609465 | 0.0601496 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.00476861 | 0.053056 | 0.0522524 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0564185 | 0.745986 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.00146525 | 0.00873843 | 0.0078972 |
Plasmodium falciparum | topoisomerase I | 0.0753523 | 1 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.00151981 | 0.00947038 | 0.00862977 |
Echinococcus granulosus | protein kinase C gamma type | 0.00476861 | 0.053056 | 0.0522524 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.00535676 | 0.0609465 | 0.0601496 |
Entamoeba histolytica | protein kinase, putative | 0.000877102 | 0.000847926 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.00383695 | 0.040557 | 0.0397427 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.00454286 | 0.0500274 | 0.0492212 |
Trichomonas vaginalis | AGC family protein kinase | 0.000877102 | 0.000847926 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.00151981 | 0.00947038 | 0.00862977 |
Brugia malayi | DNA topoisomerase I | 0.0753523 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.000877102 | 0.000847926 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3.1 mg kg-1 | In vivo effective dose against Plasmodium vinckei in mouse after ip administration of the compound | ChEMBL. | 15887971 |
ED50 (functional) | = 3.1 mg kg-1 | In vivo effective dose against Plasmodium vinckei in mouse after ip administration of the compound | ChEMBL. | 15887971 |
IC50 (functional) | = 5 nM | In vitro inhibitory concentration of the compound against Plasmodium falciparum | ChEMBL. | 15887971 |
IC50 (functional) | = 5 nM | In vitro inhibitory concentration of the compound against Plasmodium falciparum | ChEMBL. | 15887971 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 15887971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.